Home Sweat Specimen Collection as Part of Gravimetric Sweat Production Assessment for Axillary Hyperhidrosis Studies

May 2021 | Volume 20 | Issue 5 | Editorials | 580 | Copyright © May 2021


Published online April 27, 2021

Brandon Kirsch MDa, Stacy Smith MDb, Nancy Seretta BSc, Deepak Chadha MS MBA RAc

aKirsch Dermatology, Naples, FL
bCalifornia Dermatology and Clinical Research Institute, Encinitas, CA
cBrickell Biotech, Inc., Boulder, CO

Abstract
The emergence of COVID-19 has required people to minimize travel and other daily activities. These limitations have far-reaching consequences on the ability to conduct clinical research studies, which are necessary to advance the development of new medical therapies. To address these constraints, study sponsors have begun to explore modification of protocol-mandated research site visits to allow for telehealth or home visits.

A widely accepted efficacy endpoint for hyperhidrosis studies is the assessment of gravimetric sweat production (GSP).1,2,3,4 The measurements necessary to evaluate GSP are typically performed at a research site on sensitive, non-mobile balances. In anticipation of a possible COVID-related need to perform home-based sweat collection for assessment of primary axillary hyperhidrosis severity, we explored whether transporting specimens affected their weight. For our evaluation, we com-