FULL SUPPLEMENT: The 1440 nm and 1927 nm Nonablative Fractional Diode Laser: Current Trends and Future Directions

August 2020 | Volume 19 | Issue 8 | Department | s1 | Copyright © August 2020


Published online August 1, 2020

Paul M. Friedman MDa, b, Kristel D. Polder MD PhDc, Pooja Sodha MDd, Roy G. Geronemus MDb

aDermatology and Laser Surgery Center, Houston, TX bLaser & Skin Surgery Center of New York and New York University Medical Center, New York, NY cDallas Center for Dermatology and Aesthetics, Dallas, TX dGeorge Washington University, Washington, DC

Abstract
Clinical characteristics of skin exposed to ultraviolet and infrared radiation include dryness, dyschromia, laxity, roughness, sallowness, scaling, telangiectasia, and wrinkles. Fractional photothermolysis promotes skin remodeling by formation of new dermal collagen. The nonablative fractional diode laser (NFDL) system employs fractional photothermolysis to rejuvenate the skin, using 2 distinct handpieces for wavelengths of 1440 nm and 1927 nm. Fractional photothermolysis from nonablative fractional diode lasers facilitates delivery of small molecular-weight compounds, such as L-ascorbic acid, through the skin without compromising barrier function of the stratum corneum. Both handpieces of the NFDL system are effective for rejuvenation of photodamaged facial skin, providing clinical improvement in skin tone, skin texture, fine lines, and dyschromia and reducing the number of detectable skin pores. Application of the 1927 nm wavelength handpiece has shown clinical improvement of hyperpigmentation, melasma, and postinflammatory hyperpigmentation, which have been challenging to treat effectively with other laser devices. With a target chromophore of water, the infrared energy of the 1440 nm and 1927 nm NFDL system is appropriate for skin rejuvenation and treatment of dyschromia in skin of color, with a reduced risk of the adverse events observed with other nonablative and ablative fractional lasers. Clinical data have demonstrated that both the 1440 nm and 1927 nm wavelengths are effective, with high levels of patient satisfaction, transient side effects, and minimal patient downtime.

J Drugs Dermatol. 2020;19:8(Suppl 1):s3-11
In this supplement:

The 1440 nm and 1927 nm Nonablative Fractional Diode Laser: Current Trends and Future Directions
Skin exposure to ultraviolet (UV)B and UVA light and infrared radiation contributes to photoaging.1 Irradiated skin is metabolically hyperactive with epidermal hyperplasia and neoplasia, increased production of elastic fibers and glycosaminoglycans, accelerated breakdown and synthesis of collagen, and proinflammatory processes.1 Historically, skin rejuvenation of photoaged skin has involved invasive procedures.2 Over time, demand has grown for less invasive treatments and reduced patient recovery time.2,3

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