ARTICLE: Clinical Evidence of the Anti-Aging Effects of a Collagen Peptide Nutraceutical Drink on the Skin

January 2020 | Volume 19 | Issue 1 | Supplement Individual Articles | 5 | Copyright © January 2020

Published online December 23, 2019

Kathy L. Anderson DO FAOCD

Cosmetic and Medical Dermatology, Clearwater, FL Morton Plant Hospital, Clearwater, FL


A number of clinical studies support the use of this nutraceutical product. These studies are discussed in the sections below.

Collagen Peptides in Daily Oral Supplementation
Two placebo-controlled clinical trials, assessed the effects of daily oral supplementation with collagen peptides used in Skinade on skin hydration by corneometry, on collagen density by high-resolution ultrasound, and on collagen fragmentation by reflectance confocal microscopy. In addition, human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo.2

After 4 weeks of supplementation, collagen density in the dermis was increased significantly while fragmentation of the dermal collagen network was decreased significantly. After 8 weeks of intake, skin hydration was increased significantly. Both effects persisted after 12 weeks. The ex vivo experiments showed that that the collagen peptides induced collagen and glycosaminoglycan production; this could be a mechanistic explanation for the clinical effects that were noted. The researchers concluded that “oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging.”2

Collagen Peptides Increase Skin Hydration
A double-blinded, placebo-controlled trial in 2008 offered evidence-based results that the collagen peptides used in Skinade increase skin hydration.25 The study was conducted at Souken Laboratories in Tokyo, Japan, to assess the efficacy of night-time oral ingestion of a liquid supplement (Skinade) containing collagen peptides for improving skin condition. The 8-week study included 33 female volunteers, aged 40–59 years, with normal-to-dry skin. The women were divided into 3 groups each of which drank a specially formulated drink at night before bed. One group received a placebo (dextrin) in the drink and the other two groups received 10g of either fish-based or porcinebased collagen peptides in their drinks. The study lasted for 56 consecutive days, during which the subjects ingested the drinks.25

Assessment of facial-skin parameters was performed at baseline and after 4 and 8 weeks of treatment in a controlled environment with a room temperature of 22ºC ± 1°C and a relative humidity of 50% ± 10% after 30 minutes of acclimatization. Skin-moisture level was measured by conductance with a Corneometer® device (CK Electronic, Köln, Germany) at 3 different application points per subject. The rate of transepidermal water loss (TEWL) was assessed with a Tewameter® device (CK Electronic, Köln, Germany) on the line between the ear lobe and mouth edge at a 3-cm distance from the earlobe. A self-assessment questionnaire and a product-tolerance evaluation tool were also used in addition to skin imaging systems.25

The tested product increased skin hydration by up to 28% after 8 weeks, with 91% of the volunteers who drank the peptide preparations having an increase in skin hydration (n = 22; n = Cornometer skin moisture level measure) as compared with the placebo group, which demonstrated an increase in hydration of n = 2. Skin-analysis technology was used to analyze the number of deep wrinkles in the subjects; after 12 weeks, the number of deep wrinkles had increased significantly in the placebo group between baseline and 12 weeks (+30%).25

While there was no change in the placebo group, the oral intake of fish peptides over 8 weeks led to a significant increase of skin moisture level by 12%. Porcine-based peptides significantly increased skin-moisture level by 16% after 4 weeks of treatment and as much as 28% after 8 weeks of treatment (P = 0.003 versus placebo at 8 weeks). TEWL was not different between both active groups and the placebo. Thus, the researchers opined that oral intake of peptides seems to improve skin hydration effectively without affecting TEWL.25

Effect of Collagen Peptides on Cutaneous Properties
A double-blinded clinical study, in 2008, by Dermscan, in Lyon, France, was conducted to evaluate the effects of oral intake of collagen peptides on cutaneous properties versus the effects of a placebo. The study assessed the efficacy of peptides after 6 and 12 weeks during winter including the supplement’s antiwrinkle effect and biomechanical properties. Self-assessment was obtained from 47 female volunteers, aged 35–55 years, with normal-to-dry skin. These participants were given 10g of collagen peptides per day (2 x 5g) or placebo (dextrins) for 12 weeks (October–January). Investigations were focused on the dermophysiologic measures taken in a temperature and humidity conditioned room; skin moisture level (measured by Corneometer® CM 825, CK Electronic, Köln, Germany), elasticity of skin (measured by Cutometer® MPA 580, CCK Electronic, Köln, Germany); and deep-wrinkle formation measured by skin replica imaging and analysis (3D Roughness Analyzer ASA-03R; Asahi Biomed Co., Yokohama, Japan, and Quantirides® SIA). Acceptability was measured by a self-assessment questionnaire and a product-tolerance evaluation.26

The results showed increased skin hydration after 8 weeks. The Corneometer measurements showed an increase in hydration (n = 22) by 28% after 8 weeks, compared with placebo. Among the volunteers who drank the collagen peptides, 91% had increased hydration levels after 8 weeks. The study also showed that peptides prevented deep-wrinkle formation. The number of deep wrinkles significantly increased (+30%) in the placebo group between baseline and 12 weeks.26

In Vivo Effects of Oral Ingestion of Fish Collagen Peptides
A double-blinded clinical study conducted by COSderma