Polymeric Emulsion Technology Applied to Tretinoin

April 2019 | Volume 18 | Issue 4 | Supplement Individual Articles | 148 | Copyright © April 2019

Leon H. Kircik MD,a Zoe D. Draelos MD,b Diane S. Berson MDc

School of Medicine at Mount Sinai, New York, NY; Indiana School of Medicine, Indianapolis, IN; Physicians Skin Care, PLLC, Louisville, KY; DermResearch, PLLC, Louisville, KY; Skin Sciences, PLLC, Louisville, KY BDermatology Consulting Services, PLLC, High Point, NC cDepartment of Dermatology, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY

Figure5Figure6differences between the two sites were significant at all post-application assessments (P<0.001). At baseline, mean TEWL scores were 12.32 ± 0.43 and 12.42 ± 0.44 g/hm2, respectively (Figure 3). There was an immediate improvement in TEWL with test material that continued throughout the study. At 8 hours, the mean score had reduced to 5.98 ± 1.01, a 51.5% change over baseline. There was no improvement at the control site and differences between the two sites were significant at all post-application assessments (P less than 0.001). Customer perception of the novel lotion formulation was very positive with the majority of subjects responded favorably to all questions relating to the various attributes of the test material (see Figures 4A and 4B).The main benefits of the polymeric matrix reside in its ability to deliver micronized tretinoin in a more homogenous and highly dispersed form onto the skin to potentially avoid ‘hot spots’ and help deposition into skin crevasses. The polymeric network will remain at the surface of the skin and only change as a result of variations in pH, temperature, or by the act of rubbing on the skin.Follicular penetration is also an important aspect. Hair follicles contribute significantly to the penetration of topically applied substances and can serve as an effective reservoir for dermal drug delivery upon the topical application of particulate substances that extends up to 200nm into the underlying tissue. In the past, follicular penetration was ignored because it was assumed that hair follicles covered less than 0.1% of the total skin area and were therefore not relevant. However, for the scalp and face, the combined areas of follicular openings can be more