Recent Advances in Mild and Moisturizing Cleansers
January 2019 | Volume 18 | Issue 1 | Supplement Individual Articles | 80 | Copyright © January 2019
KP Ananthapadmanabhan PhD,a James J. Leyden MD,b Stacy S. Hawkins PhDc
aJL Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH bDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA cUnilever Research & Development, Trumbull, CT
The idea of low-active, water-like, low/non-foaming cleansers is highlighted by the recent growth of “micellar water” in the market place. The fact is that all conventional cleansers have “micelles” or molecular surfactant aggregates in them under conditions of cleansing and they play a significant role in the cleansing process. Micellar water is created by relatively mild, nonionic, or ultra-mild surfactants at low levels, along with low levels of solvents such as short-chain alcohols that aid in the removal of make-up and other oily materials on skin. They may also contain light moisturizers and humectants.
SUMMARY AND CONCLUSIONS
Significant advances have been made in mild and moisturizing cleanser technologies over the past 10-15 years. This includes a deeper understanding of the relative roles of SC proteins and lipids in the interaction of SC with cleanser surfactants leading to skin dryness, irritation, and erythema, and the role of co-surfactants and lipids such as stearic and palmitic acids in mitigating their effect. Typical moisturizing technologies from wash-off systems involve deposition of triglyceride oils or petrolatum during the rinse phase. The importance of cleanser base mildness even in high emollient containing moisturizing cleanser systems is now clearly established. Recent work also shows that the moisturizing technologies can move further in the direction of helping skin build better barrier by supplying actives such as fatty acids and other pro-lipids that skin can utilize in its repair process. Future trends in the cleansing area include increased use of sustainable and greener ingredients, better understanding of the skincare needs of the very elderly, and unraveling the role of skin microbiome in the context of daily skincare.
At the time of most of this work, KP Ananthapadmanabhan was an employee of Unilever. KP Ananthapadmanabhan and JJ Leyden are consultants for Unilever. S Hawkins is an employee of Unilever.
- Frosch PJ, Kligman AM. The soap chamber test - a new method for assessing the irritancy of soaps. J Am Acad Dermatol. 1979;1(1):35-41.
- Ananthapadmanabhan, KP, Lips, A, Vincent, C, et al. pH-induced alterations in stratum corneum properties. Int J Cosmet Sci. 2003;25:103-112
- Murahata, RI, Aronson MP. The relationship between solution pH and clinical irritancy for carboxylic acid-based personal washing products. J Soc Cosmet Chem. 1994;45: 239-246.
- Ananthapadmanabhan KP, Moore DJ, Subramanyan K, et al. Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing. Dermatol Ther. 2004;17(suppl 1):16-25.
- Rhein LD, Robbins CR, Fernee K, et al. Surfactant structure effects on swelling of isolated human stratum corneum. J Soc Cosmet Chem. 1986; 37:125-139.
- Imokawa G. Surfactant-induced depletion of ceramides and other intercellular lipids: implication for the mechanism leading to dehydration of the stratum corneum. Exogenous Dermatology. 2004;3:81-98.
- Rhein LD. In vitro interactions: biochemical and biophysical effects of surfactants on skin. In: Rieger MM, Rhein LD, eds. Surfactants in Cosmetics. Surfactant Science Series. New York, NY: Marcel Dekker, 1997: 397-425.
- Imokawa G. Surfactant mildness. In: Rieger MM, Rhein LD, eds. Surfactants in Cosmetics. Surfactant Science Series. New York, NY: Marcel Dekker, 1997:427-471.
- Ananthapadmanabhan KP, Subramanyan K, Rattinger GB. Moisturising cleansers. In: Leyden JJ, Rawlings AV, eds. Skin Moisturization. Cosmetic Science and Technology Series, Vol. 25. New York, NY: Marcel Dekker, Inc., 2002:405-432.
- Johnson AW, Ananthapadmanabhan KP, Hawkins S. Bar cleansers. In: Cosmetic Dermatology: Products and Procedures, 2nd Draelos ZD, ed. John Wiley and Sons Inc. 2016:83-95.
- Ananthapadmanabhan KP, Yu KK, Meyers CL, et al. Binding of surfactants to stratum corneum. J Soc Cosmet Chem. 1996;47:185-200.
- Ananthapadmanabhan K, Yang L, Vincent C, et al. A novel technology in mild and moisturizing cleansing liquids. Cosmet Dermatol. 2009;22(6):307-316.
- Regan J, Mollica L, Ananthapadmanabhan KP. A novel glycinate-based body wash - clinical investigation into ultra-mildness, effective conditioning, and improved consumer benefits. J Clin Aesth Dermatol. 2013;6(6):23-30.
- Liu M, Mollica, L, Regan, J, et al. Modified corneosurfametry as a new accelerated high throughput ex vivo methodology for predicting cleanser effects towards human skin. Int J Cosmet Sci. 2015;1-9.
- Harding CR. The stratum corneum: structure and function in health and disease. Dermatol Ther. 2004;17(Suppl 1):6-15.
- Elias PM. Epidermal lipids, barrier function, and desquamation. J Investig Dermatol. 1983;80 Suppl:44s-49s.
- Norlen L, Al-Amoudi A. Stratum corneum keratin structure, function, and formation: the cubic rod-packing and membrane templating model. J Investig Dermatol. 2004;123(4)715-732.
- J. van Smeden JV, Janssens M, Gooris GS, et al. The important role of stratum corneum lipids for the cutaneous barrier function. Biochimica et Biophysica Acta. 2014;1841:295-313.
- Benedetto AD, Kubo A, Beck LA. Skin barrier disruption: a requirement for allergen sensitization? J Investig Dermatol. 2012;132:949-963.
- Kubo A, Nagao K, Amagai M. Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases. J Clin Invest. 2012;122(2):440-447.
- Pierard GE, Goffin V, Pierard-Franchimont C. Corneosurfametry: a predictive assessment of the interaction of personal care cleansing products with human stratum corneum. Dermatology. 1994;189:152-156.
- Lips A, Ananthapadmanabhan KP, Vethamuthu M, et al. Role of surfactant micelle charge in protein denaturation and surfactant induced skin irritation. In: Surfactants in personal care products and decorative cosmetics. Rhein LD, Schlossman M, O’Lenick A, et al, eds. Surfactant Sci Ser 135. CRC Press. 2007;178-187.
- Cohen C, Dossou G, Rougier A, et al. Measurement of inflammatory mediators produced by human keratinocytes in vitro: a predictive assessment of cutaneous irritation. Toxicol in Vitro. 1991;5(5/6):407-410.
- Spiekstra SW, dos Santos GG, Scheper RJ, et al. Potential method to determine irritant potency in vitro – Comparison of two reconstructed epidermal culture models with different barrier competency. Toxicol in Vitro. 2009;23:349-355.
- de la Mazaa A, Codercha L, Lopeza O, et al. Permeability changes caused by surfactants in liposomes that model the stratum corneum lipid composition. J Am Oil Chem Soc. 1997;74(1):1-8.
- Imokawa G, Akasaki S, Minematsu Y, et al. Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res. 1989:281:45-51.
- Froebe CL, Simion FA, Rhein LD, Cagan RH, Kligman A. Impact of cleansers on the skin barrier stratum corneum lipid removal by surfactants: relation to in vivo irritation. Dermatologica. 1990:181:277-283.
- Ananthapadmanabhan KP, Mukherjee S, Chandar P. Stratum corneum fatty acids: their critical role in preserving barrier integrity during cleansing. Int J Cosmet Sci. 2013;35(4):337-345.
- Yanase K, Hatta I. Disruption of human stratum corneum lipid structure by sodium dodecyl sulphate. Int J Cos Sci. 2018;40:44-49.
- Schmid-Wendtmer MH, Korting HC. The pH of the skin surface and its impact on the barrier function. Skin Pharmacol Physiol. 2006;19:296-302.
- Knor T, Meholji?-Fetahovi? A, Mehmedagi? A. Stratum corneum hydration and skin surface ph in patients with atopic dermatitis. Acta Dermatovenerol Croat. 2011;19(4):242-247
- Hachem JP, Roelandt T, Schurer N, et al. Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. J Investig Dermatol. 2010;130(2):500–510.
- Hachem JP, Man M, Crumrine D, et al. Sustained serine proteases activity by prolonged increase in ph leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J Investig Dermatol. 2005;125:510-520.
- Blaak J, Wohlfart R, Schurer N. Treatment of aged skin with a ph 4 skin care product normalizes increased skin surface pH and improves barrier function:results of a pilot study. J Cos Dermatol Sci and Appl. 2011;1:50-58.
- Angelova-Fischer I, Fischer TW, Abels C, et al. Accelerated barrier recovery and enhancement of the barrier integrity and properties by topical application of a pH 4 vs. a pH 58 water-in-oil emulsion in aged skin. Br J Dermatol. 2018;179:471-477.
- Baranda L, González-Amaro R, Torres-Alvarez B, et al. Correlation between pH and irritant effect of cleansers marketed for dry skin. Int J Dermatol. 2002; 41:494-499.
- Hawkins S, Ananthapadmanabhan KP. Impact of cleanser pH on maintaining a healthy skin barrier. J Am Acad Dermatol. 2017;76(6):ABS 5395.
- Ananthapadmanabhan KP, Hawkins S, Foy V, et al. Role of pH in skin cleansing, manuscript in preparation. To be submitted for publicaton in Jan. 2019.
- Bragulla HH, Homberger HG. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia. J Anat. 2009;214:516-559.
- Mukherjee S, Edmunds M, Lei X, et al. Stearic acid delivery to corneum from a mild and moisturizing cleanser. J Cos Dermatol. 2010;9:202-210.
- Ertel K, Focht H. Personal cleansers: Body washes. In: Cosmetic Dermatology: Products and Procedures, 2nd. Draelos ZD, ed. John Wiley and Sons Inc. 2016:96-102.
- Zhang SL, Shiloach, A, McGuiness, H, et al. Importance of surfactant base mildness in high emollient containing cleansing systems. 2012;66(4):4996.
- Mao-Qiang M, Feingold KR, Thornfeldt CR, et al. Optimization of physiological lipids for barrier repair. J Investig Dermatol. 1996;106(5):1096-1101.
- Feingold KR, Elias PM, Role of lipids in the formation and maintenance of the cutaneous permeability barrier. Biochimica et Biophysica Acta. 2014; 1841:280-294.
- Conti A, Rogers J, Verdejo P. et. al. Seasonal influences on the stratum corneum ceramide 1 fatty acids and the influence of topical essential fatty acids. Int J Cosmet Sci. 1996;18:1-12.
- Harding C and Alexis J, Utilization of topically applied fatty acids in living skin equivalent models, 2002. Unilever internal report.
- Thakoersing VS, van Smeden J, Boiten WA, et al. Modulation of stratum corneum lipid composition and organization of human skin equivalents by specific medium supplements. Exp Dermatol. 2015;24:669-674.
- Berkers T, Visscher D, Gooris GS, et al. Topically applied ceramides interact with the stratum corneum lipid matrix in compromised ex vivo skin. Pharm Res. 2018;35:48.
- Zhang Q, Flach CR, Mendelsohn R. Topically applied ceramide accumulates in skin glyphs. Clin, Cosmet Investigational Dermatol. 2015;8:329-337.
- Stamatas GN, Nikolovski J, Mack MC, et al. Infant skin physiology and development during the first years of life: a review of recent findings based on in vivo studies. Int J Cos Sci. 2010;1-11.
- Simpson EL, Chalmers JR, Hanifin, JM, et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol. 2014;134(4):818-823.
- Farage MA, Maibach HI. Sensitive skin: closing in on a physiological cause. Contact Dermatitis. 2010:62:137-149.
- Pinto P, Rosado C, Parreira C. Is there any barrier impairment in sensitive skin?: A quantitative analysis of sensitive skin by mathematical modeling of transepidermal water loss desorption curves. Skin Res Technol. 2011;17:181-185.
- Yuan C, Pu M, Chu, C, et al. A facial cleanser containing thymol and terpineol reduced Propionibacterium acnes burden and improved acne symptoms. J Pigment Disord. 2017;4:3(Suppl):37.
KP Ananthapadmanabhan PhD firstname.lastname@example.org