Evaluation of Efficacy of a Skin Care Regimen Containing Methyl Estradiolpropanoate (MEP) for Treating Estrogen Deficient Skin

December 2019 | Volume 18 | Issue 12 | Original Article | 1226 | Copyright © December 2019

Joel L. Cohen MD

AboutSkin Research LLC, Greenwood Village, CO

more estrogen receptors and turn the pathways back on. This suggests that the longer patients have been amenorrheic, the more of their estrogen receptors have been lost, or at least have FIGURE 5: Sixty-three-year-old female Patient at baseline and week 20 after morning use of Emepelle Serum and evening use of Emepelle Night Cream. Photo Courtesy of Joel L. Cohen MD become more dormant or down-regulated.


Facial skin aging in postmenopausal females is due to cumula- tive photodamage and other intrinsic factors such as decreased collagen, reduced hydration, and loss of skin elasticity constituting the characteristics of Estrogen Deficient Skin. The presence of estrogen receptors on dermal fibroblasts and epidermal ke- ratinocytes seems to have a direct role in women’s skin health. This research examined the efficacy and tolerability of topical Methyl Estradiolpropanoate (MEP) as an anti-aging cosmeceutical with estrogen-like cutaneous effects in an open-label evaluation of postmenopausal women who had never taken hormone replacement therapy (HRT).

The significance of MEP technology is that it is a non-hormonal estrogen receptor activator that specifically addresses signs and symptoms of Estrogen Deficient Skin. Estrogen attenua- tion begins to take place in perimenopause and is accelerated in menopause. Again, it is important to indicate that MEP is a non-hormonal estrogen receptor activator that is specific to the skin. It is not a hormone, yet, has specific effects on specific skin. 

receptors only. Restoration of estrogen-like skin effects might induce the production of collagen.The ability to stimulate col- lagen and improve symptoms including dryness, dullness, and fine lines is a benefit to patients with Estrogen Deficient Skin.

In this evaluation, the efficacy of a skin care regimen contain- ing Methyl Estradiolpropanoate for the treatment of facial aging was assessed over 20 weeks. Results showed the regimen im- proved wrinkles, texture, color, and hydration. Patients in the study indicated very high satisfaction with the formulations of Emepelle Serum and the Night Cream. Younger patients in the study spectrum seemed to show significant improvement by about 8 weeks. Older patients who have been in menopause longer showed notable improvement by 20 weeks.

Further study on the effects of MEP technology may lead to bet- ter treatments for premenopausal patients and pre-juvenation skin care regimens.


Joel L. Cohen MD is a consultant for Ferndale Pharma Group, Inc., Ferndale, MI.


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Joel L. Cohen MD jcohenderm@yahoo.com