Chlorine Dioxide Complex Cleanser: A New Agent With Rapid Efficacy for Keratosis Pilaris

May 2018 | Volume 17 | Issue 5 | Original Article | 554 | Copyright © May 2018


Matthew J. Zirwas MDa and Jill Fichtel MDb

aOhio Contact Dermatitis Center, Dermatologists of Greater Columbus, Columbus, OH bDermatologists of Greater Columbus, Columbus, OH

therapeutic window.3 Alternatively, bacteria have a substantially lower intracellular reserve of glutathione that is easily depleted, allowing chlorine dioxide to become cytotoxic.Given its unique properties, there are a number of obvious uses for chlorine dioxide in dermatology, so one must wonder why it is has not already been used in dermatology. The answer lies in the practical problem of low stability – ClO2 degrades long before any product would reach the end user. One attempt to overcome this involved two bottle systems, in which two solutions that reacted to form ClO2 were mixed together just before use – while these products have existed, especially as mouth rinses and wound care agents, the formulations possible were severely limited and they were quite inconvenient. This practical problem has been overcome by a unique process that complexes the chlorine dioxide into a stable compound that retains all of the useful properties of ClO2. This chlorine dioxide complex, while giving significant flexibility in formulation, still must be formulated carefully to ensure it does not react with other components of the formulation. 

DISCLOSURES

Dr. Zirwas has served as a consultant for Valeant, Sun Products, Medimetricks, Promius, Anacor, Exeltis, Genentech, fitbit, and Smart Practice. He has been involved in the development of chlorine dioxide complex and is a part owner for AsepticMD.Dr. Fichtel has an ownership stake in Strathspey Crown and Alphaeon, neither of which have any relationship with AsepticMD.Chlorine dioxide complex was developed by Frontier Pharmaceutical and is patent pending. 

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AUTHOR CORRESPONDENCE

Matthew J. Zirwas MD matt.zirwas@gmail.com