Michèle Verschoore MDa,b and Marion Nielsen PharmDa
aL’Oréal Research & Innovation, Clichy, France bHopital Saint Louis, Centre Sabouraud, Paris, France
fine lines were found significantly decreased.26 In a multicenter blinded study, C-xyloside was also found significantly effective in alleviating skin aging signs in menopausal women.27, 28
Advances in methods for quantitative and reproducible evaluation of aging signs by clinicians, trained individuals, and panelists have resulted from outstanding progress in imaging techniques with high resolution level and software for observing, recording, and collecting data up to the ultrastructural level. Skin aging status and appearance can thus be objectively assessed to provide optimal answers to huge demand for skin anti-aging options for all skin types. New strategies using prevention, protection and boosting skin metabolism have been devised to test new evidence-based ingredients for skin antiaging bene ts. Sun and associated oxidative stress are clearly causative factors in premature altering of the facial appearance and exposed areas. These obviously make sun avoidance and protection by broad spectrum sunscreens with strong absorption in the UVA range a primary daily care, especially when coupled with antioxidants. Mild exfoliative products that smooth coarse or rough skin can prompt a faster epidermal turnover. A large range of carefully composed combinations of evidence-based ingredients can now be used for preventing or reversing troublesome concerns about the deterio- ration of the facial look and its related aged skin appearance.
Dr. Verschoore and Dr. Nielsen are full-time employees of L’Oréal Research & Innovation.
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Halder R, Rodney I., Munhutu M., et al. Evaluation and effectiveness of a photoprotective composition sunscreen) on subjects of skin of color. XXII International Pigment Cell Conference, Singapore 2014. doi: 10.1111/ pcmr.12292, Abstract P185.
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La Roche-Posay Scientific Dossier data on file
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Alexiades M., Clinical assessment of a novel dehydrojasmonate cosmeceutical, LR2412-CX, for the treatment of skin aging. J.Drugs Dermatol. 2016;15(2):209-15.
Saint-léger D, Lévêque JL, Verschoore M. The use of hydroxy acids on the skin: characteristics of C8-lipohydroxy acid. J Cosmet Dermatol. 2007;6:59-65.
Girardeau-Hubert S, Teluob S, Pageon H, et al. The reconstructed skin model as a new tool for investigating in vitro dermal fillers: increased broblast activity by hyaluronic acid. Eur J Dermatol. 2015;25(4):312-22.
Sok J, Pineau N, et al. Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative. Eur J Dermatol. 2008;18(3):297-302.
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