Palliative Treatment of Paraneoplastic Acanthosis Nigricans With Oral Florid Papillomatosis With Retinoids
September 2010 | Volume 9 | Issue 9 | Case Reports | 1151 | Copyright © September 2010
Sara L. Swineford MD and Carol R. Drucker MD
Malignant acanthosis nigricans (MAN) with oral florid papillomatosis is a rare paraneoplastic condition affecting the skin and mucocutaneous
tissues associated with an underlying malignancy. It is characterized by proliferation of keratinocytes resulting in papillomatous
change and hyperpigmentation of the skin and multiple confluent warty or verrucous lesions of the oral mucous membranes.
The oral involvement can interfere with the patient’s ability to eat and drink. There is no specific therapy for this complication. Treatment
of the underlying malignancy can lead to improvement of symptoms, but the degree of improvement varies. Here, the authors
present a case of MAN with oral florid papillomatosis associated with gastric adenocarcinoma that was treated with oral retinoids resulting in significant clinical improvement of the hyperkeratosis and hyperpigmentation as well as improved patient functionality.