Rapid Improvement in Digital Ischemia and AcralContracture in a Collodion Baby Treated With Topical Tazarotene
June 2010 | Volume 9 | Issue 6 | Case Reports | 713 | Copyright © June 2010
Rosemarie H. Liu MD, Beth Becker MD, Juliet Gunkel MD, Joyce Teng, MD, PhD
Collodion baby is a rare congenital disorder whereby affected infants are born encased in a thick, taut, shiny, translucent membrane.
The majority of babies with collodion membrane have associated disorders, most commonly nonbullous congenital ichthyosiform
erythroderma and lamellar ichthyosis. The authors report a case of collodion baby with rare complication of acral contracture, ischemia
and nail dystrophy. Topical treatment with tazarotene 0.1% gel resulted in rapid improvement. The patient developed normal
nail plates and full motor function in both hands and feet following treatment. To the authors’ knowledge, this is the first report
demonstrating the benefit of topical tazarotene for management of this rare condition in a neonate.