Two-Center Canadian Report on the Safety and Effectiveness of Evolence Breeze

Evolence Breeze, a new less viscous form of the ribose crosslinked Israeli porcine collagen Evolence, was approved for use in Canada as a cosmetic soft tissue augmenting agent on July 14, 2006.

The purpose of this report is to review a one-year, 312 subject, pan facial injection site experience. This represents our initial experience with both subject satisfaction and product safety during this one year period approximately 1.5 years after Health Canada product approval.