Solubilized Benzoyl Peroxide Versus Benzoyl Peroxide/Clindamycin in the Treatment of Moderate Acne
June 2008 | Volume 7 | Issue 6 | Original Article | 534 | Copyright © June 2008
Emil Tanghetti MD, Leon Kircik MD, David Wilson MD, Sunil Dhawan MD
Methods: Patients with acne vulgaris were randomly assigned to receive solubilized BPO 5% gel on one side of the face and a BPO 5%/clindamycin 1% combination product on the contralateral side, twice daily for 4 weeks.
Results: Of 23 patients enrolled, 100% completed the study. Reductions in lesion count with the solubilized BPO gel were at least as great as with BPO/clindamycin—and significantly greater (P≤.05) for noninflammatory lesions at week 1 and inflammatory lesions at week 4. Both regimens were generally well tolerated and patient satisfaction was comparable.
Conclusions: Solubilized BPO 5% gel monotherapy offers significantly greater efficacy, and comparable patient satisfaction, compared with BPO/clindamycin. The early reduction in lesion counts observed with the solubilized BPO gel in the absence of an antibiotic is clinically relevant.