Oral Erythromycin is Ineffective in the Treatment of Pityriasis Rosea
January 2008 | Volume 7 | Issue 1 | Original Article | 35 | Copyright © January 2008
Abbas Rasi MD, Leila Tajziehchi MD
Background: Despite the availability of various medical treatments for pityriasis rosea, a large percentage of patients fail
to achieve satisfactory results. Erythromycin is reported to be effective in the treatment of pityriasis rosea.
Methods:We designed a placebo-controlled study on 184 patients with pityriasis rosea attending the outpatient dermatology
department at Hazrat-e-Rasul Hospital in Tehran, Iran. Adult patients were treated with 200 mg of erythromycin
4 times daily and children were treated with 20 to 40 mg/kg daily in 4 divided doses. Controls were given a placebo (an
emollient cream) that was not identical in appearance. Subjects were seen at follow-up visits 2, 4, 6, and 8 weeks after
Results: Both groups were comparable with regard to sex, age, and mean duration of disease at the time of attending the
clinic. We found no significant difference between the 2 treatment groups at weeks 4, 6, and 8 after beginning of treatment.
Conclusion: In this study, prescription of oral erythromycin did not promote complete clearing of lesions.