Optimization of Narrow-Band UVB with a 5% Oleic Acid Cream in the Treatment of Psoriasis
March 2007 | Volume 6 | Issue 3 | Original Article | 290 | Copyright © March 2007
G. Martín-Ezquerra MD, M. Sánchez-Regaña MD, P. Umbert-Millet MD
Oleic acid is a monounsaturated fatty acid with a known action of penetration enhancer which has been used for various
purposes, such as a tanning increaser. Narrow-band ultraviolet B (UVB) is a also first-line treatment for psoriasis. The
purpose of this study was to evaluate if the use of a 5% oleic acid emulsion previous to the phototherapy sessions was useful
in reducing the total dosage necessary for whitening in patients with psoriasis.
Forty-four patients were included, 24 received application of the emulsion before phototherapy and 20 received phototherapy
with no emulsion. Patients received the UVB sessions just to achieve a reduction of 80% of the basal PASI.
The total dose received and number of sessions were compared within the 2 groups. A reduction in these parameters
(29.68 J/cm2 vs. 18.16 J/cm2; 24 vs. 19 sessions) was seen in the group that received application of the emulsion. However,
this was not statistically significant.
The fact that we did not achieve the statistical significance may be due to the small sample size. These results must be
cautiously interpreted and confirmed with further studies.