Hair Removal with the 3-msec Alexandrite Laser in Patients with Skin Types IV-VI: Efficacy, Safety, and the Role of Topical Corticosteroids in Preventing Side Effects
January 2007 | Volume 6 | Issue 1 | Original Article | 60 | Copyright © January 2007
Mohammed S. Aldraibi MD PhD, Dany J. Touma MD, Amor Khachemoune MD CWS
Background: Laser hair removal targets melanin in the hair shaft. The abundance of melanin in the epidermis of
patients with dark skin color has always been regarded as hazardous due to the increased incidence of side effects in this
Objective: To establish the efficacy and safety of using the 3-msec alexandrite laser in patients with skin types IV to
VI, and evaluate the role of topical corticosteroids in preventing side effects.
Methods: Thirty-seven patients with skin types IV to VI and brown or black hair were recruited and divided into 2
groups. Twenty-six patients were treated with the 18-mm spot size and 11 patients were treated with the 15-mm spot
size. Hair shafts in the treatment and control areas were counted and clipped for measurement of the thickness at the
base. The laser was used with fluences between 8 and 32 J/cm2. Two 16-cm2 areas were treated; one area was pretreated
with a class I topical corticosteroid (TCS) cream (betamethasone dipropionate) 10 minutes prelaser and twice a day for
5 days postlaser. The dynamic cooling device (DCD) spray duration was set at 90 msec, and the delay was set at 20
msec. Pain was graded on a scale from 1 to 10. Patients were followed up on day 1 and day 7 and at 1, 3, and 6 months.
Histological samples from the 2 treatment areas and control were obtained from 5 patients. At follow-up visits, side
effects were graded on a scale from 1 to 3. Hair reduction was evaluated by performing hair counts. The thickness of
hair was measured microscopically at the base. Average hair count reduction and hair thickness were recorded at the
3- and 6-month visits.
Results: Thirty-one patients completed the study. The average hair count reduction at 6 months was 35.4%. The average
hair thickness reduction was 31.2%. At one week hyperpigmentation was seen in 48.4% of the laser only treated
area and in 45.2% of laser/TCS treated area. The effect of TCS was minimal and more prominent at 1 and 3 months.
The incidence of hyperpigmentation was higher in the 15-mm group than the 18-mm group as a result of using higher
fluence. Hypopigmentation was generally preceded by crust formation and lasted up to 3 months. Reducing spot size
resulted in decreased peripheral crust formation. TCS appears to have a role in reducing the erythema and crusting.
Histopathology of both groups at day one showed necrosis of the follicular infundibulum and the inner layer of the perifollicular
epithelium. No vascular damage was seen.
Conclusion: The 3-msec alexandrite laser utilized in this study provides a safe and effective treatment achieving longterm
reduction of unwanted, pigmented hair in skin types IV and V, but is less safe in skin type VI. Using a TCS helps
in minimizing post-treatment erythema and edema; it also decreases the duration of hyperpigmentation.