The Characteristics and Utility of Solid Phase Porous Microspheres: A Review
November 2006 | Volume 5 | Issue 10 | Original Article | 969 | Copyright © November 2006
Stacy Smith MD, Vera Morhenn MD, Guy Webster MD
Topical drugs use a variety of ingredients to control the properties of the final product. Solid phase porous microspheres
(SPPM, Microsponge®) have been incorporated into several topical prescription products in an effort to improve performance
or tolerability. SPPMs provide a reservoir effect allowing more prolonged skin exposure to the active ingredient. They are used
in products for acne vulgaris, actinic keratoses, and pigmentary changes. The differences in clinical performance between existing
formulations of these common active ingredients and the formulations using SPPMs are compared and contrasted.