Wells Syndrome: An Enigmatic and Therapeutically Challenging Disease
October 2006 | Volume 5 | Issue 9 | Case Reports | 908 | Copyright © October 2006
Christina Lee Chung MD, Carrie Ann Cusack MD
Wells syndrome, also known as eosinophilic cellulitis, is an uncommon condition whose etiology often remains a mystery.
Patients present with recurrent cutaneous swellings that are often cellulitic in appearance. Histopathologic evaluation of the
skin lesions reveals a dense dermal eosinophilic infiltrate, marked edema, and characteristic “flame figures.” Notably, the picture
is devoid of vasculitis. Therapy with low-dose systemic steroids has proven variably successful. Clinical evidence lending
support for the efficacy of other medications has been, for the most part, anecdotal. We present a case of Wells syndrome,
review the literature, and discuss therapeutic options.