Primary Mucinous Carcinoma with Direct Histopathologic Evidence of Lymphatic Invasion
July 2006 | Volume 5 | Issue 7 | Case Reports | 655 | Copyright © July 2006
Melanie Warycha MD, Hideko Kamino MD, Narciss Mobini MD, Elizabeth K. Hale MD
Background: Primary mucinous carcinoma of the skin is a rare sweat gland neoplasm which occurs most commonly in the
periorbital region. Although the tumor has a propensity for local recurrence and regional spread, distant metastases are rare.
The standard treatment of primary mucinous carcinoma is wide local excision. Mohs micrographic surgery may also be
utilized in cases where tissue conservation is of utmost concern.
Objective: We present a case of primary mucinous carcinoma arising in the scalp, which was treated with wide
Methods: A case report and literature review are presented.
Results: Histopathologic evaluation revealed a well-circumscribed neoplasm characterized by lobules and aggregates of
epithelial cells embedded in abundant pools of mucin. In addition, small aggregates of neoplastic cells were found at a
distance from the primary nodule, indicative of lymphatic invasion.
Conclusion: Primary mucinous carcinoma has a high propensity for locoregional metastases and recurrence. To our
knowledge, this is the first report demonstrating direct histopathologic evidence of lymphatic invasion which correlates with
this tumor’s biologic behavior.