Intralesional Bleomycin for Warts: A Review
June 2006 | Volume 5 | Issue 6 | Original Article | 499 | Copyright © June 2006
Thomas G. Lewis MD, Ethan D. Nydorf MD
Intralesional bleomycin has been used for the treatment of warts since the 1970s. Currently, there is a limited amount of
evidence from randomized placebo-controlled trials comparing intralesional bleomycin with other local treatments for warts.
Numerous reports have been published on the use of intralesional bleomycin for the treatment of recalcitrant warts with cure
rates ranging from 14% to 99%. The majority of the data suggests that bleomycin is effective in over two-thirds of the reported
cases with minimal side effects. In this paper, we review the mechanism of action, pharmacokinetics, safety profile, supply
and storage, dosage scheme, techniques for administration, and efficacy of intralesional bleomycin for the treatment of warts.