The Incidence of Recurrent Herpes Simplex and Herpes Zoster Infection during Treatment with Arsenic Trioxide

February 2006 | Volume 5 | Issue 2 | Case Reports | 182 | Copyright © February 2006

Keyvan Nouri MD, Carlos A. Ricotti Jr. MD, Navid Bouzari MD, Halland Chen BS, Eugene Ahn MD, Bach Ardalan MD

We report the incidence of varicella zoster virus (VZV) and herpes simplex virus (HSV) infection in patients with multiple myeloma and colon cancer who were treated with arsenic trioxide for their disease. In this report, we discuss the effects of arsenic on immune system, and suggest arsenic compounds as a possible predisposing factor for viral reactivation in these patients.