Effective Treatment of Female Androgenic Alopecia with Dutasteride
September 2005 | Volume 4 | Issue 5 | Case Reports | 637 | Copyright © September 2005
Malgorzata Olszewska MD, Lidia Rudnicka MD
Dihydrotestosterone is the main molecule responsible for androgenic alopecia. Finasteride, which reduces transformation
of testosterone into dihydrotestosterone and decreases dihydrotestosterone activity, is approved for treatment of
androgenic alopecia in men. We describe the case of a 46-year-old woman with androgenic alopecia, non-responsive
to minoxidil, who initially benefited from finasteride. Due to only limited improvement after finasteride and persisting
profound psychological distress resulting from androgenic alopecia, another 5-reductase inhibitor, dutasteride, was
introduced. Clinical evaluation and trichogram were applied for assessment of dutasteride efficacy in this patient.
Additionally, mean hair diameter was monitored by means of computer dermoscopy. After 6 months of therapy, significant
improvement was observed and after 9 months the clinical diagnosis of androgenic alopecia could no longer
be made in this patient. No side effects were observed. In conclusion, theoretical data and our experience in this case
show that dutasteride might develop into a true alternative in treatment of androgenic alopecia.