The Effect of Lidocaine and Adrenaline on the Viability of Injected Adipose Tissue–– An Experimental Study in Nude Mice
May 2005 | Volume 4 | Issue 3 | Original Article | 311 | Copyright © May 2005
Oren Shoshani MD, Joseph Berger MD, Lucian Fodor MD, Yitzchak Ramon MD, Avi Shupak MD, Izhak Kehat MD, Amos Gilhar MD, Yehuda Ullmann MD
Human adipose tissue, obtained by suction-assisted lipectomy, was injected subcutaneously into the scalp of nude mice. Local anesthesia of the fat donor site consisted of a solution with 600 mg of lidocaine (0.06%) and epinephrine 1:1000000. In a control group, normal saline with no local anesthesia or epinephrine was administered to the donor site. One cc of fat was injected after centrifugation into each animal scalp. There were 10 animals in each group.
The animals were sacrificed 15 weeks after the procedure. Graft weight and volume were measured, and histologic evaluation was performed. No significant differences were demonstrated between the groups in regard with the grafts’ weight and volume and the histologic parameters investigated.
In conclusion, local anesthesia solution, consisting of lidocaine and epinephrine, does not alter the take of fat grafts, and has no influence on the adipocytes viability.