Acrokeratosis Verruciformis of Hopf: A Localized Variant
November 2004 | Volume 3 | Issue 6 | Case Reports | 687 | Copyright © November 2004
Iqbal Bukhari MD
Acrokeratosis Verruciformis of Hopf (AKV) is a rare autosomal dominant genodermatosis. It usually develops during early childhood
affecting both sexes equally. Typically, the lesions are warty to convex, brownish to skin-colored papules on the dorsa of the hands
and feet, forearms and legs. A possible relationship with Darier disease has long been postulated on a clinical basis mainly. But recently,
evidence has suggested that AKV and Darier disease are allelic disorders. I am reporting these two unrelated cases as a unilateral
localized variant of AKV.
Figure 1. Multiple pink colored convex papules on the dorsa of the
Figure 2. Hyperkeratosis, acanthosis, hypergranulosis, and church
spires appearance of the epidermis.