Treatment of Hailey-Hailey Disease with Tacrolimus Ointment and Clobetasol Propionate Foam
March 2004 | Volume 3 | Issue 2 | Case Reports | 200 | Copyright © March 2004
Saleem A Umar MD, Pradip Bhattacharjee MD, Robert T Brodell MD
Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known cure. Current therapeutic strategies
attempt to suppress Hailey-Hailey outbreaks and allow the patient to live comfortably with this condition. We have found that
applying topical tacrolimus 0.1% ointment (Protopic®) twice a day to affected areas is an excellent way to control Hailey-Hailey disease.
In addition to effectively controlling Hailey-Hailey outbreaks, tacrolimus is a relatively safe and noninvasive mode of treatment, without
significant side effects. We recommend intermittent therapy with clobetasol propionate 0.05% foam (Olux Foam®) for patients
who break through suppressive therapy with tacrolimus a few times per year. In patients with frequent outbreaks of Hailey-Hailey
disease despite suppressive therapy with tacrolimus, we recommend alternating the tacrolimus with clobetasol propionate 0.05% foam
every 6 weeks.