Imiquimod for the Treatment of Bowen's Disease and Invasive Squamous Cell Carcinoma
December 2003 | Volume 2 | Issue 6 | Case Reports | 669 | Copyright © December 2003
Keyvan Nouri, MD; Christopher O'Connell; Maria Patricia Rivas, MD
Topical imiquimod is an immune response modifier FDA approved for the treatment of anogenital warts. Recent studies have reported
its effectiveness in the treatment of some types of basal cell carcinomas. There have also been some case reports and case series
reporting success treating of squamous cell carcinoma in situ with imiquimod. We report two patients with squamous cell carcinoma
in situ and one with invasive squamous cell carcinoma treated with 5% imiquimod cream. Lesions were located on shin, posterior
shoulder, and nasal tip. 5% imiquimod cream was applied at night for six weeks. Side effects included erythema and crusting in
one patient. Biopsies taken four weeks after treatment revealed no residual squamous cell carcinoma in situ or squamous cell carcinoma.
Topical 5% imiquimod cream is becoming established as a promising treatment for squamous cell carcinoma in situ. It also
seems to be an alternative treatment for some cases of squamous cell carcinoma.