March 2003 | Volume 2 | Issue 2 | Original Article | 124 | Copyright © March 2003
Treatment of plantar warts is often difficult and may be painful, often employing destructive treatment modalities. We
report the successful treatment of a patient with a large plantar wart using Imiquimod 5% cream under occlusion with a
40% salicylic acid pad. This combination treatment modality likely allows successful delivery of Imiquimod through the
thick skin on the plantar surface. Once penetrated, an anti-viral state is created by upregulating specific cytokines to
eradicate the human papilloma virus (HPV).