While difficult to quantify precisely, dermatophyte infections are both common and widely distributed worldwide.1-7 Estimates based upon epidemiologic data from studies done in a variety of countries and continents suggest that some 20% to 25% of the worldâ€™s population will be affected by superficial cutaneous fungal infections at least once during their lifetimes. Although fungal infections of the skin, hair, and nails can include those caused by candida species, the yeasts responsible for tinea versicolor, and nondermatophyte molds, the vast majority of such infections are due to dermatophytic organisms.3,6 Thus, it is further estimated that 10% to 15% of the worldâ€™s population will acquire at least one dermatophytosis.6 In the United States, the most recent large scale investigation disclosed that, on average, over 4 million healthcare provider (HCP) visits directly related to cutaneous fungal infection occurred annually (range 3,583,590-6,754,460), the overwhelming majority due to dermatomycoses. This represented some 0.4% of all ambulatory healthcare visits during the time period under study.5
It is worth suggesting that this situation will not likely abate in the near future. Well accepted predisposing factors are not likely to decrease in either incidence or prevalence. Consider that onychomycosis is more prevalent among those with diabetes, peripheral vascular disease, and immunocompromise, and amongst the elderly.8,9 In fact, the changing demographic characteristics of the population living in industrialized countries (mirrored in nations with emerging economies) includes: an increased number of elderly, an increased prevalence of obesity, diabetes, and peripheral vascular disease, a longer survival of those with endogenous immunocompromised conditions, and the commonplace administration of iatrogenic immunosuppression (including for solid organ transplantation). These factors may well lead to even more onychomycosis.10 Since onychomycosis is frequently associated with tinea pedis, and fungal infections of the foot are often felt to be responsible for dermatophytoses of the groin and/or trunk,11 it is clear that such fungal infections are not going to diminish in the coming decades.
Moreover, in addition to the foregoing, social mores may lead to expansion of dermatophytoses. For example, earlier and more frequent participation in sports activities and the â€œworkoutâ€ craze among young adults could lead to more frequent micro-trauma to the nail unit and the pedal skin; and exposure to common public sports facilities (including showers and locker rooms) are also considered to predispose to onychomycosis. 12 Finally, virtually every factor enumerated above as having the potential to lead to a persistent epidemiologic onychomycosis problem has also, independently, been implicated in the development of tinea pedis, an equally important reservoir of pathogenic fungi.13
At present, there is little hope of eradicating dermatophytoses, as is the case with smallpox and nearly the case with polio. Faced with the inevitability of dermatophytosis, it is no wonder that the HCP remains in search of simple, safe, convenient, and reliable therapies. That search has been further complicated by the relatively recent development, approval, and marketing of newer antifungal agents. New formulations of pre-existing molecules (1% econazole nitrate foam and 2% naftifine hydrochloride cream and gel) and novel molecules (10% efinaconazole solution, 1% luliconazole cream, 2% sertaconazole nitrate cream, and 5% tavaborole solution) have recently appeared in the marketplace and re-awakened an interest in clinical mycology.
Should not picking the â€œbestâ€ agent for a given disease be as simple as going to the package insert of older and newer agents