Treatment of Moderate to Severe Acne and Scars With a 650-Microsecond 1064-nm Laser and Retinoid

J Drugs Dermatol. 2020;19(6):   doi:10.36849/JDD.2020.5108

Michael H. Gold M.D.a, Natalia E. Manturova MD PHDb, Larisa S. Kruglova MD PHDc, Evgeniya V. Ikonnikova MDc

Laser procedures for acne and acne scars have traditionally been postponed for at least 6 to 8 months after the end of systemic retinoid therapy. Lower dosages with more modern laser devices having unique energy parameters of high power in microsecond pulse durations have made it possible to administer laser therapy during or shortly after completion of retinoid therapy, thus reducing the risk of side effects.

The Fate of Active Acne and Acne Scars Following Treatment With Fractional Radiofrequency

J Drugs Dermatol. 2019;18(12):1268-1272.

Bruce E. Katz MD

Acne vulgaris (AV) is a common skin disorder that may result in long-lasting acne scars. Techniques such as delivering fractional radiofrequency (RF) energy through miniature pins or needles have been utilized to manage active acne and acne scars. Skin restoration through dermal remodeling, neo-collagenesis, neo-elastogenesis, and epidermal re-newal are typical results of such treatments.

New Polymeric Once-Daily Retinoid 0.045% Lotion Formulation for Moderate-to-Severe Acne: Pooled Phase 3 Pediatric Analysis

J Drugs Dermatol. 2020;19(6): doi:10.36849/JDD.2020.4959

Lawrence F. Eichenfield MD,ª Emil A. Tanghetti MD,b Eric Guenin PharmD PhD MPH,^c Gina Martin MOT,^d Radhakrishnan Pillai PhD^d

Acne vulgaris affects approximately 85% of adolescents. A specific topical retinoid is efficacious and safe for acne treatment but irritation limits its use. The objective was to evaluate efficacy, safety, and tolerability of a new retinoid 0.045% lotion formulation in patients aged 10-13 and 14-17 years with moderate-to-severe acne.

Truncal Acne: A Neglected Entity

J Drugs Dermatol. 2019;18(12):1205-1208.

James Q. Del Rosso DO,^a Linda Stein-Gold MD,^b Charles Lynde MD,^c Emil Tanghetti MD,^d Andrew F. Alexis MD MPH^e

Truncal acne – acne vulgaris involving the chest, back, or shoulders – is thought to be present in more than half of patients with acne. Because the study of acne has been focused on the face, there are sparse data in the literature about the clinical characteristics and management options for truncal acne. It is thought that the pathogenic process is similar between the face and the back, suggesting that treatments studied on the face may be suitable for use on the back. It is not uncommon for patients to omit discussion of truncal acne with their treating physician, and it is likely that non-facial acne is under-diagnosed and under-treated. Scarring and pigmentary problems are common sequelae of acne on the trunk, underscoring the need for early and effective treatment as a preventive measure.

Patient-Reported Outcomes in Acne Patients With Skin of Color Using Adapalene 0.3%-Benzoyl Peroxide 2.5%: A Prospective Real-World Study

J Drugs Dermatol. 2019;18(6):514-520.

Janet DuBois MD,^a Gavin Chun Wei Ong MD,^b Gitanjali Petkar MBBS, DDV,^c, Luiz Mauricio Costa Almeida MD,^d Rajeev Chavda MD,^e Nabil Kerrouche MSc,^f and Andrew F. Alexis MD MPH^g

This was an open-label interventional study conducted in 3 countries (Mauritius, Singapore, and USA) in subjects of Asian, Latin-American, or black/African-American ethnicity, with an Investigator’s Global Assessment (IGA) of moderate or severe facial acne (enrollment 2:1), and FST IV to VI. For 16 weeks, subjects applied 0.3% A/BPO (once daily) and utilized a skin care regimen (oil control foam wash and oil control moisturizer SPF30). Assessments included quality of life (QoL) and subject questionnaires, IGA, Investigator’s Global Assessment of Improvement (GAI), postinflammatory hyperpigmentation (PIH; if present at baseline), and safety.

A Cohort Study Using a Facial Cleansing Brush With Acne Cleansing Brush Head and a Gel Cleanser in Subjects With Mild-to-Moderate Acne and Acne-Prone Skin

J Drugs Dermatol. 2019;18(11):1140-1145.

Michael H. Gold MD FAAD,a Glynis R. Ablon MD FAAD,b Anneke Andriessen PhD,c Vivian W. Bucay MD FAAD,d David J. Goldberg MD JD,e Jeremy B. Green MD FAAD,f Deirdre Hooper MD FAAD,g Stephen H. Mandy MD FAAD,h Mark S. Nestor MD PhD,i Arisa Ortiz MD FAAD FACMSj

Acne vulgaris is a highly prevalent skin condition that can adversely affect the quality of life. Acne-predisposed skin is in a state of subclinical inflammation leading to skin barrier dysfunction. A multi-center cohort study was designed to evaluate clinical efficacy and safety of twice daily facial cleansing using an oscillatory sonic brush, acne brush head, and cleansing gel for 4 weeks.

Androgens, Androgen Receptors, and the Skin: From the Laboratory to the Clinic With Emphasis on Clinical and Therapeutic Implications

J Drugs Dermatol. 2020;19(3 Suppl 1):s30-35.

James Q. Del Rosso DO,^a Leon H. Kircik MD,^b Linda Stein Gold MD,^c Diane Thiboutot MD^d

The effects of androgens on human skin include growth and differentiation of sebaceous glands, terminal hair growth, epidermal barrier function, wound healing, and modification of the cutaneous microbiome. Androgens exert their activities via ligand formation with intracytoplasmic androgen receptors which can then translocate to the nucleus and interact with genetic androgen response elements to influence signaling cascades.

A Phase 2b, Randomized, Double-Blind Vehicle Controlled, Dose Escalation Study Evaluating Clascoterone 0.1%, 0.5%, and 1% Topical Cream in Subjects With Facial Acne

J Drugs Dermatol. 2019;18(6):570-575.

Alessandro Mazzetti MD,^a Luigi Moro PhD,^a Mara Gerloni PhD,^a Martina Cartwright PhD^b

Primary objective: to compare the safety and efficacy of topical creams containing clascoterone 0.1% (twice daily [BID]), 0.5% (BID), or 1% (daily [QD] or BID) versus vehicle (QD or BID) in male and female subjects ≥12 years with facial acne vulgaris.