Could a Migraine Medication Clear Cystic Acne? A Curious Case Suggests New Possibilities
What if a drug you prescribe for migraines could also help treat cystic acne?
A recent JDD case report shares the unexpected and encouraging story of a 30-year-old woman with long-standing, treatment-resistant cystic acne, particularly on her chin. She had tried it all: antibiotics, topicals, hormonal therapy for PCOS. But nothing made a lasting impact.
That changed when she was prescribed rimegepant, a CGRP (calcitonin gene-related peptide) receptor antagonist, to manage her migraines. Within just four weeks, her cystic acne significantly improved. Painful lesions faded, and cosmetic discomfort diminished, without any changes to her dermatologic regimen.
CGRP, known for its role in neurogenic inflammation and vasodilation, is already a major target in migraine treatment. But it’s also active in inflammatory skin conditions like acne and rosacea. This case hints at a fascinating new possibility: Could CGRP antagonists modulate neurogenic inflammation in the skin, reduce sebaceous gland activity, and offer a new avenue for acne therapy?
While it’s just a single case, it adds to a growing body of evidence suggesting cross-talk between neurology and dermatology. More research is clearly needed, but this case is a compelling reminder that innovation sometimes arrives from unexpected specialties.
J Drugs Dermatol. 2025;24(6):636-637.
