Comparing Biostimulatory Agents for Skin Rejuvenation
Injectable biostimulators like poly-L-lactic acid (PLLA-SCA™) and calcium hydroxylapatite (CaHA-R) are used to stimulate collagen production in aging skin, but their molecular effects differ. A 13-week study involving 21 patients with nasolabial fold (NLF) contour deficiencies compared gene expression after treatment with these agents.
Results showed PLLA-SCA activated genes linked to extracellular matrix production and regenerative pathways, with minimal inflammation. In contrast, CaHA-R triggered more pro-inflammatory gene activity, suggesting less regenerative potential. Understanding these pathways can inform personalized skin rejuvenation strategies.
