Issue Archive
May 2018 | Volume 17 | Issue 5
Editorials
Senior Resident Peer-to-Peer Case Studies
The content of these case studies, ideal to review during peer study groups, was developed by Elizabeth Robinson, MD and Jennifer Aronica, MD under the guidance of dermatologist Adam Friedman, MD, FAA...
Read MoreGene Expression Analysis Differentiates Melanomas from Spitz Nevi
Introduction: Pediatric Spitz nevi can pose significant diagnostic challenges to both clinicians and dermatopathologists when the current image-recognition based gold standard is employed. PRAME (pref...
Read MoreChronic Nasolabial Fold Seborrheic Dermatitis Successfully Controlled With Crisaborole
Chronic Nasolabial Fold Seborrheic Dermatitis Successfully Controlled With Crisaborole...
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Original Articles
Demographic and Tumor Characteristics of Patients Younger Than 50 Years With Nonmelanoma Skin Cancer Referred for Mohs Micrographic Surgery
BACKGROUND: An increase in nonmelanoma skin cancer (NMSC) in younger patients has been reported. Many are treated with Mohs micrographic surgery (MMS). OBJECTIVE: Investigate patient and tumor charac...
Read MoreVismodegib and the Hedgehog Pathway Inhibitors: A Historical Perspective to Current Clinical Application
Vismodegib (Erivedge, Genentech-Roche) is the first in class of Hedgehog pathway inhibitors approved for treatment of metastatic basal cell carcinoma (BCC), or locally advanced BCC that has recurred a...
Read MoreA Retrospective Analysis of Complication Rates in Mohs Micrographic Surgery Patients With Clinically Large Tumors and Tumors With Aggressive Subclinical Extension
Background: Clinically large cutaneous tumors and those with aggressive subclinical extension (ASE) often require wider margins and increased operative time during Mohs micrographic surgery (MMS). Our...
Read MoreDermatologist Practices During Total Body Skin Examinations: A Survey Study
Though screening for skin cancer is an essential practice in dermatology, limited data are published on dermatologists' total body skin examination (TBSE) behaviors. We surveyed 6500 dermatologists on...
Read MoreFacial Basal Cell Carcinoma in Patients Younger Than 40
Introduction: The incidence of basal cell carcinoma in the population younger than 40 years is rising, and a majority of basal cell carcinomas occur on the head and neck. Our objective was to determin...
Read MoreComplex Regional Pain Syndrome: What the Dermatologist Should Know
Reflex sympathetic dystrophy is a subtype of complex regional pain syndrome, a condition characterized by persistent post-injury extremity pain. Temperature and sweating changes, edema, mobility chang...
Read MoreThe Role of IL-17 in the Human Immune System and Its Blockage as a Treatment of Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis
Interleukin 17 (IL-17) functions as a bridge between the innate and adaptive immunity. In addition to being a crucial defense mechanism against extracellular pathogens, it plays a significant role in ...
Read MoreFactors Affecting Dermatologists’ Use of a 31-Gene Expression Profiling Test as an Adjunct for Predicting Metastatic Risk in Cutaneous Melanoma
Importance: A 31-gene expression profile (31-GEP) test to predict metastatic risk in patients with cutaneous malignant melanoma has previously been validated and is available for clinical use. The imp...
Read MoreDegradation of Hylauronic Acid Fillers Using Hyaluronidase in an In Vivo Model
Introduction: Soft tissue fillers manufactured with hyaluronic acid (HA) dominate the filler market around the world and the fact that HA can be dissolved using hyaluronidase contributes to its popula...
Read MoreChlorine Dioxide Complex Cleanser: A New Agent With Rapid Efficacy for Keratosis Pilaris
Chlorine dioxide complex™ is a new molecule to dermatology that is a unique, non-toxic, broad spectrum anti-microbial and keratolytic compound. Chlorine dioxide has been used as an antiseptic in...
Read MoreA Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair
Hair loss is a complex problem that generates significant concern for those who are affected. Patients seeking medical treatments have limited options, and are increasingly turning to natural therapie...
Read MoreA Natural Cream-to-Powder Formulation Developed for the Prevention of Diaper Dermatitis in Diaper-Wearing Infants and Children: Barrier Property and In-Use Tolerance Studies
Introduction: Diaper dermatitis is a common condition that develops in the diaper area due to factors such as elevated moisture, increased skin surface pH, and exposure to irritants from urine and fec...
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Features
Longitudinal Melanonychia Biopsy: What Not to Do
The nail matrix biopsy is an important technique in confirming or excluding a diagnosis of melanoma in a patient with longitudinal melanonychia. Dermatologists are the first-line diagnosticians for th...
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Case Reports
Nodule Formation Following Treatment With Hyaluronic Acid Fillers: A Report of Two Challenging Cases
Nodule formation can be a potentially disfiguring adverse event of soft tissue fillers. Limited treatment consensus exists regarding the optimal approach for addressing recurrent and persistent nodule...
Read MoreWidespread Skin Necrosis Secondary to Gemcitabine Therapy
Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Common dermatologic reactions associated with gemcitabine include alopec...
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