Treatment of Melasma and the Use of Intense Pulsed Light: A Review

November 2012 | Volume 11 | Issue 11 | Original Article | 1316 | Copyright © November 2012


Lisa Zaleski DO LCDR MC USN,a* Sabrina Fabi MD,b and Mitchel P. Goldman MDb

aDepartment of Dermatology, U.S. Naval Medical Center Okinawa, Okinawa, Japan bDermatology/Cosmetic Laser Associates, La Jolla, CA
*The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Navy, Department of Defense, or U.S. Government.

  1. Wang CC, Hui CY, Sue YM, Wong WR, Hong HS. Intense pulsed light for the treatment of refractory melasma in Asian persons. Dermatol Surg. 2004;30(9):1196-1200.
  2. Kroon MW, Wind BS, Beek JF, et al. Nonablative 1550-nm fractional laser therapy versus triple topical therapy for the treatment of melasma: a randomized controlled pilot study. J Am Acad Dermatol. 2011;64(3):516-523.
  3. Rusciani A, Motta A, Fino P, Menichini G. Treatment of poikiloderma of Civatte using intense pulsed light source: 7 years of experience. Dermatol Surg. 2008;34(3):314-319.
  4. Bak H, Lee HJ, Chang SE, Choi JH, Kim MN, Kim BJ. Increased expression of nerve growth factor receptor and neural endopeptidase in the lesional skin of melasma. Dermatol Surg. 2009;35(8):1244-1250.
  5. Wind BS, Kroon MW, Meesters AA, et al. Non-ablative 1,550 nm fractional laser therapy versus triple topical therapy for the treatment of melasma: a randomized controlled split-face study. Lasers Surg Med. 2010;42(7):607-612.
  6. Katz TM, Glaich AS, Goldberg LH, Firoz BF, Dai T, Friedman PM. Treatment of melasma using fractional photothermolysis: a reports of eight cases with long-term follow-up. Dermatol Surg. 2010;36(8):1273-1280.
  7. Lee HS, Won CH, Lee DH, et al. Treatment of melasma in Asian skin using a fractional 1,550-nm laser: an open clinical study. Dermatol Surg. 2009;35(10):1499-1504.
  8. Wattanakrai P, Mornchan R, Eimpunth S. Low-fluence Q-switched neodymium-doped yttrium aluminum garnet (1,064 nm) laser for the treatment of facial melasma in Asians. Dermatol Surg. 2010;36(1):76-87.
  9. Chan NP, Ho SG, Shek SY, Yeung CK, Chan HH. A case series of facial depigmentation associated with low fluence Q-switched 1,064 nm Nd:YAG laser for skin rejuvenation and melasma. Lasers Surg Med. 2010;42(8):712-719.
  10. Waniphakdeedecha R, Manuskiatti W, Siriphukpong S, Chen TM. Treatment of melasma using variable square pulse Er:YAG laser resurfacing. Dermatol Surg. 2009;35(3):475-481.
  11. Kang WH, Yoon KH, Lee ES, et al. Melasma: histopathological characteristics in 56 Korean patients. Br J Dermatol. 2002;146(2):228-237.
  12. Galeckas KJ, Collins M, Ross EV, Uebelhoer NS. Split-face treatment of facial dyschromia: pulsed dye laser with a compression handpiece versus intense pulsed light. Dermatol Surg. 2008;34(5):672-680.
  13. Goldman MP, Weiss RA, Weiss MA. Intense pulsed light as a nonablative approach to photoaging. Dermatol Surg. 2005;31(9 Pt 2):1179-1187.
  14. Goldman MP, Weiss RA. Treatment of poikiloderma of Civatte on the neck with an intense pulsed light source. Plast Reconstr Surg. 2001;107(6):1376-1381.
  15. Li YH, Wu Y, Chen JZ, et al. Application of a new intense pulsed light device in the treatment of photoaging skin in Asian patients. Dermatol Surg. 2008;34(11):1459-1464.
  16. Park JM, Tsao H, Tsao S. Combined use of intense pulsed light and Qswitched ruby laser for complex dyspigmentation among Asian patients. Lasers Surg Med. 2008;40(2):128-133.
  17. Weiss RA, Goldman MP, Weiss MA. Treatment of poikiloderma of Civatte with an intense pulsed light source. Dermatol Surg. 2000;26(9):823-827.
  18. Li YH, Wu Y, Chen JZ, et al. A split-face study of intense pulsed light on photoaging skin in Chinese population. Lasers Surg Med. 2010;42(2):185-191.
  19. Hedelund L, Due E, Bjerring P, Wulf HC, Haedersdal M. Skin rejuvenation using intense pulsed light: a randomized controlled split-face trial with blinded response evaluation. Arch Dermatol. 2006;142(8):985-990.
  20. Negishi K, Wakamatsu S, Kushikata N, Tezuka Y, Kotani Y, Shiba K. Full-face photorejuvenation of photodamaged skin by intense pulsed light with integrated contact cooling: initial experiences in Asian patients. Lasers Surg Med. 2002;30(4):298-305.
  21. Nootheti PK, Pettit KA, Yosowitz G, Goldman MP. Clinical improvement of photodamaged skin after a single intense pulsed light treatment. Am J Cosmet Surg. 2007;24(1):15-20.
  22. Feng Y, Zhao J, Gold MH. Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanisms of intense pulsed light. J Drugs Dermatol. 2008;7(3):273-279.
  23. JØrgensen GF, Hedelund L, Haedersdal M. Long-pulsed dye laser versus pulsed light for photodamaged skin: a randomized split-face trial with blinded response evaluation. Lasers Surg Med. 2008;40(5):293-299.

Address for Correspondence

Lisa Zaleski DO LCDR MC USNlisa.zaleski@med.navy.mil
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