efficacy by the study participants with >93% expressing overall
satisfaction at all time points. These results and those from the
stratum corneum lipid analysis are evidence for the benefits of
using the studied ceramide-containing moisturizer for dry skin
even in warmer, high-humidity conditions.
CONCLUSION
This 4-week, ceramide-containing moisturizer study was able to
demonstrate an improved skin water content through corneometry,
a reduction in subject perceived sensory discomfort, and
dermatologist investigator assessed resolution of the signs of
dry skin. Improvement continued for 48 hours after moisturizer
withdrawal.
DISCLOSURES
The study was funded by the L’Oréal Research & Innovation Dpt.
Dr. Zoe Draelos received funding from L'Oréal to conduct the
research presented in this manuscript. Nada Baalbaki, Shelby
Cook, Susana Raab are employees of L’Oréal Research and Innovation.
Gene Colón is an employee of L’Oréal USA, Inc. (CeraVe).
REFERENCES
1. Draelos ZD. The effect of ceramide-containing skin care products on eczema resolution duration. Cutis. 2008;81:87-91.
2. Coderch L, Lopez O, Maza A, Parra JL. Ceramides and skin function. Am J Clin Dermatol. 2003;4:107-129.
3. Wertz PW, Miethke MC, Long SA, et al. The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol. 1985;84:410-412.
4. Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223.
5. DiNardo A, Wertz P, giaetti A, Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol. 1998;78:27-30.
6. Imokawa G, Abe A, Jin K, Higaki Y, et al. Decreased level of ceramides in stratum corneum of atopic dermatits: an etiologic factor in atopic dry skin? J Invest Dermatol. 1990;96(4):523-526.
7. Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate irritated skin. Int J Dermatol. 2008;47(8):812-819.
8. Beradesca E, Vignoli GP, Oresajo C, et al. Prevention of barrier function damage by topically applied ceramides. Proceedings of the 17th IFSCC International Congress; Yokohama; October 13-16, 1992:881-888.
2. Coderch L, Lopez O, Maza A, Parra JL. Ceramides and skin function. Am J Clin Dermatol. 2003;4:107-129.
3. Wertz PW, Miethke MC, Long SA, et al. The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol. 1985;84:410-412.
4. Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223.
5. DiNardo A, Wertz P, giaetti A, Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol. 1998;78:27-30.
6. Imokawa G, Abe A, Jin K, Higaki Y, et al. Decreased level of ceramides in stratum corneum of atopic dermatits: an etiologic factor in atopic dry skin? J Invest Dermatol. 1990;96(4):523-526.
7. Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate irritated skin. Int J Dermatol. 2008;47(8):812-819.
8. Beradesca E, Vignoli GP, Oresajo C, et al. Prevention of barrier function damage by topically applied ceramides. Proceedings of the 17th IFSCC International Congress; Yokohama; October 13-16, 1992:881-888.
AUTHOR CORRESPONDENCE
Zoe Diana Draelos MD zdraelos@northstate.net
