Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits

January 2016 | Volume 15 | Issue 1 | Supplement Individual Articles | 24 | Copyright © January 2016


Vic A. Narurkar MD,a Sabrina G. Fabi MD FAAD FAACS,b Vivian W. Bucay MD FAAD,c Ruth Tedaldi MD,d Jeanine B. Downie MD,e Joshua A. Zeichner MD,f Kimberly Butterwick MD,g Amy Taub MD,h Kuniko Kadoya PhD,i Elizabeth T. Makino BS MBA CCRA,i Rahul C. Mehta PhD,i and Virginia L. Vega PhDi

aBay Area Laser Institute, San Francisco, CA
bDepartment of Dermatology, University of California San Diego, CA
cBucay Center for Dermatology and Aesthetics, San Antonio, TX
dDermatology Partners, Inc, Wellesley, MA
eImage Dermatology, Montclair, NJ
fDepartment of Dermatology, Mount Sinai Hospital, New York, NJ
gCosmetic Laser Dermatology, La Jolla, CA
hAdvanced Dermatology, Lincolshire, IL
iResearch & Development, SkinMedica Inc., an Allergan Company, Irvine, CA

  1. Pasonen-Seppänen S, Hyttinen JM, Rilla K, et al. Role of CD44 in the organization of keratinocyte pericellular hyaluronan. Histochem Cell Biol. 2012;137(1):107-120.
  2. Mier PD, Wood M. The acid mucopolysaccharides of mammalian skin. Br J Dermatol. 1969;81(7):528-533.
  3. Tammi R, Ripellino JA, Margolis RU, Tammi M. Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe. J Invest Dermatol. 1988;90(3):412-414.
  4. Toole BP. Hyaluronan and its binding proteins, the hyaladherins. Curr Opin Cell Biol. 1990;2(5):839-844.
  5. Knudson CB, Knudson W. Hyaluronan-binding proteins in development, tissue homeostasis, and disease. FASEB J. 1993;7(13):1233-1241.
  6. Bernstein EF, Underhill CB, Hahn PJ, Brown DB, Uitto J. Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycans. Br J Dermatol. 1996;135(2):255-262.
  7. Rieger M. Hyaluronic acid in cosmetics. Cosm Toilet. 1998;113:35-42.
  8. Simpson RM, Meran S, Thomas D, et al. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. Am J Pathol. 2009;175(5):1915-1928.
  9. Robert L, Robert AM, Renard G. Biological effects of hyaluronan in connective tissues, eye, skin, venous wall. Role in aging. Pathol Biol (Paris). 2010;58:187-198.
  10. Pavicic T. Efficacy and tolerability of a new monophasic, double-crosslinked hyaluronic acid filler for correction of deep lines and wrinkles. J Drugs Dermatol. 2011;10(2):134-139.
  11. Cordero A, Leon-Dorantes G, Pons-Guiraud A, et al. Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging. J Cosmet Dermatol. 2011;10(2):110-117.
  12. Madison KC. Barrier function of the skin: “la raison d’etre” of the epidermis. J Invest Dermatol. 2003;121(2):231-241.
  13. Elias PM. Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers. Exp Dermatol. 1996;5(4):191-201.
  14. Sugawara T, Iwamoto N, Akashi M, et al. Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice. J Dermatol Sci. 2013;70:12-18.

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