The strength of the present study is its comparison with the excimer laser, the current first-line phototherapy for the treatment of mild to moderate psoriasis vulgaris. Results are nearly identical throughout the study and treatment-related adverse events were not observed. Limitations are the small number of patients and the short follow-up time. The encouraging results justify additional studies with more patients and longer follow-up time.
CONCLUSION
The efficacy and tolerance of the 650-microsecond laser has
been shown to be equivalent to that of the excimer laser for the
treatment of mild to moderate psoriasis vulgaris of the arms
and legs.
DISCLOSURES
Dr. Nestor has received research grants from Aerolase and is a
consultant to Aerolase. Drs. Fischer and Arnold have no disclosures.
REFERENCES
1. Sbidian E, Chaimani A, Garcia-Doval I, et al. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev. 2017; Dec 22;12:CD011535.
2. Zhang P, Wu MX. A clinical review of phototherapy for psoriasis. Lasers Med Sci. 2018;33:173-180.
3. Bónis B, Kemény L, Dobozy A, et al. 308 nm UVB excimer laser for psoriasis. Lancet. 1997;350(9090):1522.
4. Taibjee SM, Cheung ST, Laube S, Lanigan SW. Controlled study of excimer and pulsed dye lasers in the treatment of psoriasis. Br J Dermatol. 2005;153:960-966.
5. He YL, Zhang XY, Dong J, et al. Clinical efficacy of a 308 nm excimer laser for treatment of psoriasis vulgaris. Photodermatol Photoimmunol Photomed. 2007;23:238-241.
6. Mudigonda T, Dabade TS, Feldman SR. A review of protocols for 308 nm excimer laser phototherapy in psoriasis. J Drugs Dermatol. 2012;11:92-97.
7. Abrouk M, Levin E, Brodsky M, et al. Excimer laser for the treatment of psoriasis: safety, efficacy, and patient acceptability. Psoriasis (Auckl). 2016;6:165-173.
8. Higgins E, Ralph N, Ryan S, et al. A randomised half body prospective study of low and medium dose regimens using the 308 nm excimer laser in the
2. Zhang P, Wu MX. A clinical review of phototherapy for psoriasis. Lasers Med Sci. 2018;33:173-180.
3. Bónis B, Kemény L, Dobozy A, et al. 308 nm UVB excimer laser for psoriasis. Lancet. 1997;350(9090):1522.
4. Taibjee SM, Cheung ST, Laube S, Lanigan SW. Controlled study of excimer and pulsed dye lasers in the treatment of psoriasis. Br J Dermatol. 2005;153:960-966.
5. He YL, Zhang XY, Dong J, et al. Clinical efficacy of a 308 nm excimer laser for treatment of psoriasis vulgaris. Photodermatol Photoimmunol Photomed. 2007;23:238-241.
6. Mudigonda T, Dabade TS, Feldman SR. A review of protocols for 308 nm excimer laser phototherapy in psoriasis. J Drugs Dermatol. 2012;11:92-97.
7. Abrouk M, Levin E, Brodsky M, et al. Excimer laser for the treatment of psoriasis: safety, efficacy, and patient acceptability. Psoriasis (Auckl). 2016;6:165-173.
8. Higgins E, Ralph N, Ryan S, et al. A randomised half body prospective study of low and medium dose regimens using the 308 nm excimer laser in the