Randomized, Investigator-Blinded Study to Compare the Efficacy and Tolerance of a 650-microsecond, 1064-nm YAG Laser to a 308-nm Excimer Laser for the Treatment of Mild to Moderate Psoriasis Vulgaris

February 2020 | Volume 19 | Issue 2 | Original Article | 176 | Copyright © February 2020


Published online January 9, 2020

Mark S. Nestor MD PhD,a Daniel Fischer DO MS,a David Arnold DOa

aCenter for Clinical and Cosmetic Research, Aventura, FL bDepartment of Dermatology and Cutaneous Surgery, Department of Surgery, Division of Plastic Surgery, University of Miami Miller School of Medicine, Miami, FL









Local Skin Reactions
Median local skin reactions for the lesional and perilesional areas are shown in Table 7. Since visual inspection revealed that median reaction scores were identical on both sides of the body, values are not separated according to the laser. Median reaction scores were zero for each reaction parameter. Maximum values ranged from 0 to 2 for erosion/ulceration and erythema and from 0 to 3 for scaling. One subject was burned during treatment with the excimer laser. The subject had erythema and tenderness at the treated lesions.

Although pain during or after treatment was significantly greater for the 650-microsecond laser (P=0.0002), no subject withdrew from the study for this reason.