Metallic Taste as a Side Effect of Topical Fluorouracil Use

October 2011 | Volume 10 | Issue 10 | Case Reports | 1201 | Copyright © October 2011


Sandra Y. Han MDa and Summer Youker MDb

aDepartment of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, IL bDepartment of Dermatology, University of California, Davis School of Medicine, Sacramento, CA

  1. Dillaha CJ, Jansen GT, Honeycutt WM, et al. Further studies with topical 5-fluorouracil. Arch Dermatol. 1965;92:410-418.
  2. Levy S, Furst K, Chern W. A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis. Clin Ther. 2001;23:908-919.
  3. Erlanger M, Martz G, Ott F, et al. Cutaneous absorption and urinary excretion of 6-14C-5-fluorouracil ointment applicated in an ointment to healthy and diseased human skin. Dermatologica. 1970;140(suppl 1):7-14.
  4. Johnson MR, Hageboutros A, Wang K, et al. Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res. 1999;5:2006-2011.

ADDRESS FOR CORRESPONDENCE

Sandra Han MDDepartment of DermatologyNorthwestern University, Feinberg School of Medicine676 N St. Clair, Suite 1600Chicago, IL 60611Phone: (312) 695-8106Fax: (312) 695-0537sandra.han@northwestern.edu
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