Management of Impending Necrosis Associated With Soft Tissue Filler Injections

September 2011 | Volume 10 | Issue 9 | Case Reports | 1007 | Copyright © September 2011


Steven H. Dayan MD FACS,a,b John P. Arkins BS,c Clyde C. Mathison MDd

aChicago Center for Facial Plastic Surgery, Chicago, IL bDepartment of Otolaryngology, University of Illinois at Chicago, Chicago, IL cDeNova Research, Chicago, IL dDepartment of Otolaryngology, Head and Neck Surgery at University of Illinois at Chicago. Chicago, IL

  1. Grunebaum LD, Bogdan Allemann I, Dayan S, Mandy S, Baumann L. The risk of alar necrosis associated with dermal filler injection. Dermatol Surg. 2009;35(suppl 2):1635-1640.
  2. Schanz S, Schippert W, Ulmer A, Rassner G, Fierlbeck G. Arterial embolization caused by injection of hyaluronic acid (Restylane). Br J Dermatol. 2002;146(5):928-929
  3. Coleman SR. Avoidance of arterial occlusion from injection of soft tissue fillers. Aesthet Surg J. 2002;22(6):555-557.
  4. Narins RS, Jewell M, Rubin M, Cohen J, Strobos J. Clinical conference: Management of rare events following dermal fillers — focal necrosis and angry red bumps. Dermatol Surg. 2006;32(3):426-434.
  5. Hirsch RJ, Cohen JL, Carruthers JD. Successful management of an unusual presentation of impending necrosis following a hyaluronic acid injection embolus and a proposed algorithm for management with hyaluronidase. Dermatol Surg. 2007;33(3):357-360.
  6. Georgescu D, Jones Y, McCann JD, Anderson RL. Skin necrosis after calcium hydroxylapatite injection into the glabellar and nasolabial folds. Ophthal Plast Reconstr Surg. 2009;25(6):498-499.
  7. Hanke CW, Higley HR, Jolivette DM, Swanson NA, Stegman SJ. Abscess formation and local necrosis after treatment with Zyderm or Zyplast collagen implant. J Am Acad Dermatol. 1991;25(2 Pt 1):319-326.
  8. Dayan SH, Arkins JP, Brindise R. Soft tissue fillers and biofilms. Facial Plast Surg. 2011;27(1):23-28.
  9. Dayan SH. Managing Filler Complications. Merge. Allured Business Media. 2010:22-23.
  10. Spear M. What are the necessary practice competencies for two providers: Dermal fillers and botulinum toxin type A injections? Plast Surg Nurs. 2010;30(4):226-246; quiz 247-228.
  11. Cohen JL. Understanding, avoiding, and managing dermal filler complications. Dermatol Surg. 2008;34(suppl 1):92S-99S.
  12. Brody HJ. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement. Dermatol Surg. 2005;31(8 Pt 1):893-897
  13. Johnsson C, Hallgren R, Elvin A, Gerdin B, Tufveson G. Hyaluronidase ameliorates rejection-induced edema. Transpl Int. 1999;12(4):235-243.
  14. Maroko PR, Hillis LD, Muller JE, et al. Favorable effects of hyaluronidase on electrocardiographic evidence of necrosis in patients with acute myocardial infarction. N Engl J Med. 1977;296(16):898-903.
  15. Maroko PR, Libby P, Bloor CM, Sobel BE, Braunwald E. Reduction by hyaluronidase of myocardial necrosis following coronary artery occlusion. Circulation. 1972;46(3):430-437.
  16. Engstrom-Laurent A, Feltelius N, Hallgren R, Wasteson A. Raised serum hyaluronate levels in scleroderma: An effect of growth factor induced activation of connective tissue cells? Ann Rheum Dis. 1985;44(9):614-620.
  17. Hamerman D, Wood DD. Interleukin 1 enhances synovial cell hyaluronate synthesis. Proc Soc Exp Biol Med. 1984;177(1):205-210.
  18. Heldin P, Laurent TC, Heldin CH. Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts. Biochem J. 1989;258(3):919-922.
  19. Yaron M, Yaron I, Wiletzki C, Zor U. Interrelationship between stimulation of prostaglandin E and hyaluronate production by poly (I) . poly (C) and interferon in synovial fibroblast culture. Arthritis Rheum. 1978;21(6):694-698.
  20. Suzuki M, Asplund T, Yamashita H, Heldin CH, Heldin P. Stimulation of hyaluronan biosynthesis by platelet-derived growth factor-BB and transforming growth factor-beta 1 involves activation of protein kinase C. Biochem J. 1995;307(Pt 3):817-821.
  21. Nitro-BID [package insert]. Melville, NY: E. Fougera & Co.; 2010.
  22. Davis SC, Cazzaniga AL, Ricotti C, et al. Topical oxygen emulsion: A novel wound therapy. Arch Dermatol. 2007;143(10):1252-1256.

ADDRESS FOR CORRESPONDENCE

Steven H. Dayan, MDChicago Center for Facial Plastic SurgeryDepartment of Otolaryngology atUniversity of Illinois at Chicago845 North Michigan AvenueSuite 923 EastChicago, IL 60611Phone: (312) 335-2070Fax: (312) 335-2074sdayan@drdayan.com