4th, 2018.
6. Osterwalder A. The Business Model Ontology - A Proposition In A Design Science Approach. (PhD thesis). University of Lausanne; 2004
7. Osterwalder A. Yves Pigneur. Business Model Generation: A Handbook for Visionaries, Game Changers, and Challengers. 1st ed. John Wiley and Sons; 2010.
8. Step 3: Pathway to Approval. U.S. Food and Drug Administration website. https://www.fda.gov/ForPatients/Approvals/Devices/ucm405381.htm. February 9, 2018. Accessed April 4, 2018.
9. DiMasi, J, Grabowski, H, Hansen, R. Innovation in the pharmaceutical industry: New estimates of R&D costs. J Health Econ. 2016;47:20-33.
10. Morimoto S, Kumahara Y. A patient with psoriasis cured by 1 alphahydroxyvitamin D3. Med J Osaka Univ. 1985;35(3-4):51-4. PubMed PMID: 4069059.
11. Leaute-Labreze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008;358(24):2649-51.
12. [No author listed.] “The Real History Behind the Birth of Botoxâ€. [online] Reader’s. Available at: http://www.readersdigest.ca/health/beauty/birthbotox/ view-all
13. [No author listed.] "The Nobel Prize in Physiology or Medicine 1950". Nobelprize.org. Nobel Media AB 2014. Web. 8 Dec 2017. http://www. nobelprize.org/nobel_prizes/medicine/laureates/1950/
14. Binns, W, James, LF, Shupe, JL. Toxicosis of veratrum californicum in ewes and its relationship to a congenital deformity in lambs. Ann N Y Acad Sci, 1964;111: 571–576. doi:10.1111/j.1749-6632.1964.tb53124.x
15. [No author listed]. “The Nobel Prize in Physiology or Medicine 1995". Nobelprize.org. Nobel Media AB 2014. Web. 8 Dec 2017. http://www. nobelprize.org/nobel_prizes/medicine/laureates/1995/
16. Axelson M, Liu K, Jiang X, He K, Wang J, Zhao H, Kufrin D, Palmby T, Dong Z, Russell AM, Miksinski S, Keegan P, Pazdur R. U.S. Food and Drug Administration approval: vismodegib for recurrent, locally advanced, or metastatic basal cell carcinoma. Clin Cancer Res. 2013;19(9):2289-93. doi: 10.1158/1078-0432.CCR-12-1956. Epub 2013 Mar 20. PubMed PMID: 23515405.
17. Hönigsmann H. History of phototherapy in dermatology. Photochem Photobiol Sci. 2013 Jan;12(1):16-21. doi: 10.1039/c2pp25120e. PubMed PMID: 22739720.
18. [No author listed.] "The Nobel Prize in Physiology or Medicine 1903". Nobelprize.org. Nobel Media AB 2014. Web. 8 Dec 2017. http://www. nobelprize.org/nobel_prizes/medicine/laureates/1903/
19. Parrish JA, Fitzpatrick TB, Tanenbaum L, Pathak MA. Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light. N Engl J Med. 1974;291:1207-1211
20. Maiman TH. Stimulated optical radiation in ruby. Nature. 1960187, 493-94.
21. Anderson RR, Parrish JA. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science. 1983;220:524-527
22. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34:426-38
23. Soong S-J, Ding S, Coit, et al. Predicting survival outcome of 116 localized melanoma: An electronic prediction tool based on the 117 AJCC melanoma database. Ann Surg Oncol. (in press).
24. Breslow A. Thickness, cross-sectional areas and depth of invasion in the eh prognosis of cutaneous melanoma. Ann Surg. 1970;172:902-908
6. Osterwalder A. The Business Model Ontology - A Proposition In A Design Science Approach. (PhD thesis). University of Lausanne; 2004
7. Osterwalder A. Yves Pigneur. Business Model Generation: A Handbook for Visionaries, Game Changers, and Challengers. 1st ed. John Wiley and Sons; 2010.
8. Step 3: Pathway to Approval. U.S. Food and Drug Administration website. https://www.fda.gov/ForPatients/Approvals/Devices/ucm405381.htm. February 9, 2018. Accessed April 4, 2018.
9. DiMasi, J, Grabowski, H, Hansen, R. Innovation in the pharmaceutical industry: New estimates of R&D costs. J Health Econ. 2016;47:20-33.
10. Morimoto S, Kumahara Y. A patient with psoriasis cured by 1 alphahydroxyvitamin D3. Med J Osaka Univ. 1985;35(3-4):51-4. PubMed PMID: 4069059.
11. Leaute-Labreze C, Dumas de la Roque E, Hubiche T, et al. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008;358(24):2649-51.
12. [No author listed.] “The Real History Behind the Birth of Botoxâ€. [online] Reader’s. Available at: http://www.readersdigest.ca/health/beauty/birthbotox/ view-all
13. [No author listed.] "The Nobel Prize in Physiology or Medicine 1950". Nobelprize.org. Nobel Media AB 2014. Web. 8 Dec 2017. http://www. nobelprize.org/nobel_prizes/medicine/laureates/1950/
14. Binns, W, James, LF, Shupe, JL. Toxicosis of veratrum californicum in ewes and its relationship to a congenital deformity in lambs. Ann N Y Acad Sci, 1964;111: 571–576. doi:10.1111/j.1749-6632.1964.tb53124.x
15. [No author listed]. “The Nobel Prize in Physiology or Medicine 1995". Nobelprize.org. Nobel Media AB 2014. Web. 8 Dec 2017. http://www. nobelprize.org/nobel_prizes/medicine/laureates/1995/
16. Axelson M, Liu K, Jiang X, He K, Wang J, Zhao H, Kufrin D, Palmby T, Dong Z, Russell AM, Miksinski S, Keegan P, Pazdur R. U.S. Food and Drug Administration approval: vismodegib for recurrent, locally advanced, or metastatic basal cell carcinoma. Clin Cancer Res. 2013;19(9):2289-93. doi: 10.1158/1078-0432.CCR-12-1956. Epub 2013 Mar 20. PubMed PMID: 23515405.
17. Hönigsmann H. History of phototherapy in dermatology. Photochem Photobiol Sci. 2013 Jan;12(1):16-21. doi: 10.1039/c2pp25120e. PubMed PMID: 22739720.
18. [No author listed.] "The Nobel Prize in Physiology or Medicine 1903". Nobelprize.org. Nobel Media AB 2014. Web. 8 Dec 2017. http://www. nobelprize.org/nobel_prizes/medicine/laureates/1903/
19. Parrish JA, Fitzpatrick TB, Tanenbaum L, Pathak MA. Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light. N Engl J Med. 1974;291:1207-1211
20. Maiman TH. Stimulated optical radiation in ruby. Nature. 1960187, 493-94.
21. Anderson RR, Parrish JA. Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science. 1983;220:524-527
22. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med. 2004;34:426-38
23. Soong S-J, Ding S, Coit, et al. Predicting survival outcome of 116 localized melanoma: An electronic prediction tool based on the 117 AJCC melanoma database. Ann Surg Oncol. (in press).
24. Breslow A. Thickness, cross-sectional areas and depth of invasion in the eh prognosis of cutaneous melanoma. Ann Surg. 1970;172:902-908
AUTHOR CORRESPONDENCE
Clark C. Otley MD Otley.Clark@mayo.edu