Inflammaging in Dermatology: A New Frontier for Research

February 2021 | Volume 20 | Issue 2 | Original Article | 144 | Copyright © February 2021


Published online January 25, 2021

Abid Haque MD,a Heather Woolery-Lloyd MDb

aHoward University, College of Medicine,Washington, DC
bUniversity of Miami, Miller School of Medicine, Frost Department of Dermatology and Cutaneous Surgery, Miami, FL

Inflammaging in Dermatology
We reviewed the existing, published literature to understand the current state of research in dermatology regarding inflammaging and the skin. We searched the following key words: “inflammaging” + “skin”, “inflammaging” + “dermatology”, “inflammageing” + “skin”, “inflammageing” + “dermatology”. After eliminating articles that were not relevant to dermatology, we found 15 articles focusing on inflammaging in dermatology. These covered a variety of topics from UV- induced inflammaging to the anti-inflammaging properties of certain botanicals. The articles and abstracts are summarized in Table 1.

As a number of the articles from our search indicate, inflammaging in the skin is known to be a multifaceted and sophisticated pathological process influenced by reactive oxygen species (ROS), TNF-alpha, IL-1, IL-6, IL-8, neutrophils, matrix metalloproteinases (MMPs), the complement system, and