ble 3). They were also asked to compare their baseline photograph (taken before they had started using the
hydroquinone/L-ascorbic acid treatment system) with their current appearance (viewed in a hand mirror) before rating the following parameters: the efficacy of the
hydroquinone/L-ascorbic acid treatment system; how the hydroquinone/L-ascorbic acid treatment system compared to previous skin care treatments they had used; and their
satisfaction with the overall appearance of their skin (Table 3).
Statistical Analyses
Patients who discontinued early were excluded from the post-baseline efficacy analyses. For five of the
investigator evaluations (overall integrated assessment of photodamage, overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity), median
values at each timepoint were compared with the baseline value using a signed-rank test. An α of ≤.05 was considered statistically significant.
