Evidence of Barrier Deficiency in Rosacea and the Importance of Integrating OTC Skincare Products into Treatment Regimens

April 2021 | Volume 20 | Issue 4 | Original Article | 384 | Copyright © April 2021


Published online March 16, 2021

Hilary Baldwin MDa, Andrew F. Alexis MD MPHb, Anneke Andriessen PhDc, Diane S. Berson MD FAADd, Patricia Farris MD FAADe, Julie Harper MDf, Edward Lain MD FAADg, Shari Marchbein MDh, Linda Stein Gold MDi, Jerry Tan FRCPCj

aAcne Treatment & Research Center, Brooklyn, NY
bIcahn School of Medicine at Mount Sinai, New York, NY
cRadboud UMC Nijmegen, Andriessen Consultants, Malden, The Netherlands
dCornell University Weill Medical College, Weill Cornell Medical Center, Dermatology, New York, NY
eTulane University School of Medicine, New Orleans, LA; Sanova Dermatology, Metairie, LA
fThe Dermatology and Skin Care Center of Birmingham, Birmingham, AL
gSanova Dermatology, Austin TX; Austin Institute for Clinical Research, Austin, TX
hNYU School of Medicine, New York, NY
iHenry Ford Health System, Detroit, MI
jRoyal College of Physicians and Surgeons of Canada; Schulich School of Medicine and Dentistry, Department of Medicine, Western University, Windsor, ON, Canada; Windsor Clinical Research Inc; The Healthy Image Centre, Windsor, ON, Canada

characteristic study. Cutis. 2009;84:72–76.
29. Lonne-Rahm SB, Fischer T, Berg M. Stinging and rosacea. Acta Derm Venerol. 1999;79:460–461.
30. Ni Raghallaigh S, Bender K, Lacey N, Brennan L, Powell FC. The fatty acid profile of the skin surface lipid layer in papulopustular rosacea. Br J Dermatol. 2014;171(2):259-266 )
31. Lynde CW, Tan J, Skotnicki S, Andriessen A. Clinical insights about the role of skin pH in inflammatory dermatological conditions. J Drugs Dermatol. 2019;18(12)S-1:1-16.
32. Van Zuuren EJ, van der Linden MMD, Arents BWM. Rosacea treatment guideline for The Netherlands. Br J Dermatol. 2020 182:1504-1506. https:// doi.org/10.1111/bjd.19073
33. Del Rosso JQ, Thiboutot D, Gallo R et al. consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 1: a status report on the disease state, general measures, and adjunctive skin care. Cutis. 2013; 92: 234– 40.
34. Tan J, Berg M, Gallo RL, Del Rosso JQ. Applying the phenotype approach for rosacea to practice and research. Br J Dermatol. 2018;
35. Asai Y, Tan J, Baibergenova A et al. Canadian clinical practice guidelines for rosacea. J Cutan Med Surg. 2016; 20:432– 45.
36. Marson JW, Baldwin HE. Rosacea: a wholistic review and update from pathogenesis to diagnosis to therapy. Int J Dermatol. 2020;59(6):e175-e182)
37. Strugar TL, Kuo A, Seite S, Lin M, Lio P. Connecting the dots: from skin barrier dysfunction to allergic sensitization, and the role of moisturizers in repairing the skin barrier. J Drugs Dermatol. 2019;18(6):581.
38. Wang B, McHugh BJ, Qureshi A, Campopiano DJ, Clarke DJ, Fitzgerald JR, et al. IL-1beta-induced protection of keratinocytes against staphylococcus aureus-secreted proteases is mediated by human beta-defensin 2. J Invest Dermatol. 2017;137:95–105. [PMC free article] [PubMed] [Google Scholar]
39. Skotnicki S, Shulgan C. Beyond soap: The real truth about what you are doing to your skin and how to fix it for a beautiful healthy glow: Penguin Canada. 2018.
40. Proksch E. pH in nature, humans and skin. J Dermatol. 2018;45:1044-1052)
41. Baia de Melo Magalhães Goncalves MM, Soares Rodrigues Tavares de Pina ME. Dermocosmetic care for rosacea. Braz J Pharm Sci. 2017;53(4);e00182. http://dx.doi.org/10.1590/s2175-97902017000400182
42. Zeichner JA, Del Rosso JQ. Multivesicular emulsion ceramide-containing moisturizers: an evaluation of their role in the management of common skin disorders. J Clin Aesthet Dermatol. 9(12):26-32. PMID: 28210396 | PMCID: PMC5300724
43. Crudele J, Kim E, Murray K, Regan J. The importance of understanding consumer preferences for dermatologist recommended skin cleansing and care products. J Drugs Dermatol. 2019;18(1 Suppl):s75-79.
44. Abokwidir M, Feldman SR. Rosacea management. Skin Appendage Disord. 2016;2:26–34. doi: 10.1159/000446215
45. Del Rosso JQ. The use of moisturizers as an integral component of topical therapy for rosacea: clinical results based on the assessment of skin characteristics study. Cutis. 2009 84(2):72-6.
46. Baldwin H, Santoro F, Lachmann N, Teissedre S. A novel moisturizer with high sun protection factor improves barrier function and the visible appearance of rosacea-prone skin. J Cosmet Dermatol. 2019;18:1686-1692. doi: 10.1111/ jocd.12889
47. Grivet-Seyve M, Santoro F, Lachmann N. Evaluation of a novel very high sunprotection- factor moisturizer in adults with rosacea-prone sensitive skin. Clin Cosmet Investing Dermatol. 2017;(10):211-219.
48. Salsberg J, Andriessen A, Abdulla S, et al. A review of protection against exposome factors impacting facial skin barrier function with 89% mineralizing thermal water. J Cosmet Dermatol. 2019;18(3):815-820.

AUTHOR CORRESPONDENCE

Anneke Andriessen PhD anneke.a@tiscali.nl