ARTICLE: Clinical Evidence of the Anti-Aging Effects of a Collagen Peptide Nutraceutical Drink on the Skin

January 2020 | Volume 19 | Issue 1 | Supplement Individual Articles | 5 | Copyright © January 2020

Published online December 23, 2019

Kathy L. Anderson DO FAOCD

Cosmetic and Medical Dermatology, Clearwater, FL Morton Plant Hospital, Clearwater, FL


1. Patel N, Padhtrare D, Saudagar R. Newer trends in cosmetology. World J Pharm Pharmaceutical Sci. 2015;4(3):483–502.
2. Asserin J, Lati, E, Shioya B, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: Evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14(4):291–301.
3. Sakai S, Yasuda R, Sayo T, Ishikawa O, Inoue S. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol. 2000;114(6):1184–7.
4. Oba C, Ohara H, Morifuji M, Ito K, Ichikawa S, Kawahata K, Koga J. Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice. Photodermatol Photoimmunol Photomed. 2013;29(4):204–11.
5. Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol. 2010;37(4):330–8.
6. Shimizu J, Asami N, Katatoka A, et al. Oral collagen-derived dipeptides, prolyl-hydroxyproline and hydroxyprolyl-glycine, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun. 2015;456(2):626–30.
7. Tanaka M, Koyama V, Nomura Y. Effects of collagen peptide ingestion on UV-B–induced skin damage. Biosci Biotechnol Biochem. 2009;73(4):930–2.
8. Liang J, Pei X, Zhang Z, Wang N, Wang J, Li Y. The protective effects of longterm oral administration of marine collagen hydrolysate from chum salmon on collagen matrix homeostasis in the chronological aged skin of Sprague– Dawley male rats. J Food Sci. 2010;75(8):H230–8.
9. Zague V, de Freitas V, da Costa Rosa M, de Castro GÁ, Jaeger RG, Machado-Santelli GM. Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity. J Med Food. 2011;14(6):618–24.
10. Matsuda N, Koyama Y, Hosaka Y, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo). 2006;52(3):211–5.
11. Shigemura Y, Iwai K, Morimatsu F, et al. Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem. 2009:57(2):444–9.
12. Albini A, Adelmann-Grill BC. Collagenolytic cleavage products of collagen type I as chemoattractants for human dermal fibroblasts. Eur J Cell Biol. 1985;36(1):104–7.
13. Postlethwaite AE, Seyer JM, Kang AH. Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proc Natl Acad Sci U S A. 1978;75:871–5.
14. The Collagen Supplement Debate. Aesthetics 2014. Online document at:
15. Halper J, Kjaer M. Basic components of connective tissues and extracellular matrix: Elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins. Adv Exp Med Biol. 2014;802:34–47.
16. Buonocore D, Lazzeretti A, Tocabens P, et al. Resveratrol–procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 2012;5:159–65.
17. Zanna N. Evidence base and benefits associated with a collagen-based nutraceutical drink. J Aesthetic Nurs. 2017;6(3):1–8.
18. Magnuson BA, Appleton J, Ryan B, Matulka RA Oral developmental toxicity study of methylsulfonylmethane in rats. Food Chem Toxicol. 2007;45(6): 977–84.
19. Kannan R, Ng MJ. Cutaneous lesions and vitamin B12 deficiency. Can Fam Physician. 2008;54(4):529–32.
20. Telang PS. Vitamin C in dermatology. Indian Dermatol Online J. 2013;4(2):143–6.
21. Pilkington SM, Rhodes LE. Omega-3 fatty acids and skin. In: Krutmann J, Humbert P, eds. Nutrition for Healthy Skin: Strategies for Clinical and Cosmetic Practice. Berlin: Springer; 2011:91–108.
22. Anthonavage M, Benjamin R, Withee E. Effects of oral supplementation with methylsulfonylmethane on skin health and wrinkle reduction. Natural Med J. 2015;7(11). Online document at: journal/2015-11/effects-oral-supplementation-methylsulfonylmethane-skinhealth- and-wrinkle-reduction.
23. NHS [National Health Service] B Vitamins and Folic Acid: Vitamins and Minerals. Online document at: vitamin-b/.
24. Mount Sinai. Vitamin H (Biotin). Online document at: health-library/supplement/vitamin-h-biotin.
25. Souken Laboratories. Double-Blind Placebo-Controlled Trial of Oral Supplementation of Peptan Collagen Peptides in Improving Skin Condition: Study YNTKK–2008–4144. Tokyo: Souken Laboratories; 2008.
26. Dermscan. Evaluation of the Effects of an Oral Intake of Peptan Collagen Peptides on Cutaneous Properties Versus Placebo. Lyon: Dermscan; 2008.
27. Cosderma. Visualisation and Assessment Versus Placebo of the Effect in Vivo of the Oral Intake of Hydrolysed Collagen on Skin Properties: Investigational Products. Rousselot Peptan F versus Maltodextrine PYC. Bordeaux, France: Cosderma; 2012.
28. Santi Skin Labs. Can a 90-day Supply of Skinade Improve Global Skin Rejuvenation of the Face? United Kingdom: Santi Labs; 2008 29. Watanabe-Kamiyama M, Shimizu M, Kamiyama S, et al. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem. 2010;58(2):835-41.
30. Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, Striker G, Vlassara H Circulating glycotoxins and dietary advanced glycation endproducts: two links to in ammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci. 2007;62(4):427–33.