INTRODUCTION
Aging is a multifactorial process, leading to changes at every level of the skin. Extrinsic factors such as environmental and ultraviolet (UV) damage lead to accumulation of free radicals, oxidative stress, and DNA damage. Intrinsic factors include reduced cell turnover, as well as loss of collagen, elastin, and hyaluronic acid. In combination, this leads to pigmentation, dull skin tone, textural changes, and fine and deep skin rhytides.1-3 Laser resurfacing remains the gold standard to improve signs of photodamage and aging, but despite advances in technology, the procedure is often carries a long healing time, patient discomfort, and post-procedure erythema.4-5
A novel rejuvenation and healing system (Calecim® Multi Action Cream and Professional serum, Cell Research Corporation, Singapore) utilizes red deer umbilical cord lining mesenchymal stem cell conditioned media (USCCM) to optimize healing post procedure. This patented protein mix contains growth factors, cytokines, amino acids, peptides, and extracellular matrix proteins, to aid in wound and tissue healing processes, as well as improve fine lines, elasticity, pigmentation, and erythema.6-7 In this prospective, randomized, controlled, double-blind clinical trial, the authors analyze the efficacy and tolerability of USCCM cream and serum compared to vehicle pre- and post- ablative resurfacing of the face.
A novel rejuvenation and healing system (Calecim® Multi Action Cream and Professional serum, Cell Research Corporation, Singapore) utilizes red deer umbilical cord lining mesenchymal stem cell conditioned media (USCCM) to optimize healing post procedure. This patented protein mix contains growth factors, cytokines, amino acids, peptides, and extracellular matrix proteins, to aid in wound and tissue healing processes, as well as improve fine lines, elasticity, pigmentation, and erythema.6-7 In this prospective, randomized, controlled, double-blind clinical trial, the authors analyze the efficacy and tolerability of USCCM cream and serum compared to vehicle pre- and post- ablative resurfacing of the face.
MATERIALS AND METHODS
The study was approved by a centralized Institutional Review Board and conducted in accordance with Good Clinical Practices conforming to the ethical guidelines of the 1975 Declaration of Helsinki.
Participants
Twenty healthy subjects, aged 36–70, with skin type I to IV, with moderate to severe photodamage, graded as Class II–III and Score 4–9 on the Fitzpatrick-Goldman Classification of Wrinkling and Degree of Elastosis Scale (Table 1) were eligible for enrollment. Subjects were excluded if they were pregnant or breastfeeding; had systemic steroid use, dermabrasion, deep chemical peel, non-ablative laser, ablative laser, microfocused ultrasound, light or radiofrequency treatment to the face within 6 months; had microdermabrasion or light to medium chemical
Participants
Twenty healthy subjects, aged 36–70, with skin type I to IV, with moderate to severe photodamage, graded as Class II–III and Score 4–9 on the Fitzpatrick-Goldman Classification of Wrinkling and Degree of Elastosis Scale (Table 1) were eligible for enrollment. Subjects were excluded if they were pregnant or breastfeeding; had systemic steroid use, dermabrasion, deep chemical peel, non-ablative laser, ablative laser, microfocused ultrasound, light or radiofrequency treatment to the face within 6 months; had microdermabrasion or light to medium chemical
