So far, scientific knowledge about the combined use of HA fillers and laser treatment is still limited.4 Our results revealed synergistic effects of fractional ablative laser treatment and injection of HA dermal fillers supporting a combination of both treatments. This combined treatment promotes tissue modulators such as Serpin E1, which plays a key role in the cutaneous wound repair program.5
The present study showed that skin models are a reliable tool to investigate the molecular effects of dermal fillers and their combination with laser treatment.
2. Marquardt Y, Amann PM, Heise R, et al. Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments. Lasers Surg Med. 2015;47(3):257-265.
3. Fan Y, Choi TH, Chung JH, Jeon YK, Kim S. Hyaluronic acid-cross-linked filler stimulates collagen type 1 and elastic fiber synthesis in skin through the TGF-beta/Smad signaling pathway in a nude mouse model. J Plast Reconstr Aesthet Surg. 2019;72(8):1355-1362.
4. Urdiales-Galvez F, Martin-Sanchez S, Maiz-Jimenez M, Castellano-Miralla A, Lionetti-Leone L. Concomitant use of hyaluronic acid and laser in facial rejuvenation. Aesthetic Plast Surg. 2019;43(4):1061-1070.
5. Simone TM, Higgins CE, Czekay RP, et al. SERPINE1: A molecular switch in the proliferation-migration dichotomy in wound-"activated" keratinocytes. Adv Wound Care (New Rochelle). 2014;3(3):281-290.