Biological Effects of Hyaluronic Acid-Based Dermal Fillers and Laser Therapy on Human Skin Models

September 2020 | Volume 19 | Issue 9 | Features | 897 | Copyright © September 2020

Published online August 24, 2020

Laura Huth PhDa, Yvonne Marquardt a, Ruth Heise PhDa, Katharina Fietkau a, Jens Malte Baron MDa,b, Sebastian Huth PhDa*

aDepartment of Dermatology and Allergology, Medical Faculty, RWTH Aachen University, Aachen, Germany bInterdisciplinary Center for Laser Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany

*Sebastian Huth and Jens Malte Baron contributed equally to this work.

of genes that are associated with tissue remodeling (eg, Serpin E1, MMP3) as well as a downregulation of differentiation markers (eg, KRT1, FLG) (Figures 2C and 2D), reflecting the enhanced cell proliferation in the epidermal layer of the 3D skin model. Moreover, qRT-PCR analysis confirmed the stimulating effects of the combined treatment on Serpin E1 (Figure 2E).


This study aimed at understanding more precisely the biological effects of HA-based fillers, their combination with laser treatment and their differences to PLLA-based fillers. Our data show enhancing effects of dermal fillers on epidermal