containing barrier lipids may help maintain the protective skin barrier and soothe with long-term moisturizing benefits.1-3
The current consensus paper explores challenges, and current treatment approaches in neonatal and infant normal and sensitive skin conditions and the role of ceramides containing moisturizers.
A literature review explored present clinical guidelines, treatment options, and therapeutic approaches addressing neonatal and infant normal and sensitive skin conditions. For this purpose, searches were made in PubMed and on Google Scholar, on 13-15 January 2020, for English-language literature (2010– 2020) using the following terms:
Pediatric skin; maturation; skin physiology of neonates and Infants; vernix; infant skin barrier physiology; function; pathology; dysfunction; epidermal maturation's markers; protection infant skin barrier; fragility of epidermis in infants; depletion of stratum corneum lipids; atopic dermatitis (AD); AD pathogenesis; skin barrier function; skin microbiome in AD; pediatric AD guidelines; algorithm; pediatric AD consensus recommendations; prevention; treatment; maintenance; topical treatment; moisturizers; emollients; skincare in newborns and infants; ceramides; ceramide containing skincare; skin maturation and moisturization.
The selected publications were manually reviewed for additional resources.
The searches yielded 106 papers deemed clinically relevant to neonatal and infant normal and sensitive skin conditions. After the exclusion of duplicates and articles not related to neonatal and infant skin, 64 papers were included (Figure 1). Of the selected articles, there were twelve guidelines (Table 1), one epidemiology study, twenty-four reviews that included six systematic reviews. (Table 2). Twenty-one clinical trials were selected, which addressed neonatal and infant skin conditions. Table 3 illustrates the selected papers on newborn and infant skin barrier function.
Role of the Panel
The expert panel of pediatric dermatologists and dermatologists who commonly treat pediatric skin conditions convened for a one-day meeting (February 7, 2020; Miami Beach, FL), to define statements on neonatal and infant normal and sensitive skin conditions and the role of ceramides containing moistur-