croneedling was repeated after 15 days. The 2015 subjects were also instructed to wear sunscreen after suture removal.
The modified Vancouver Scar Scale4 (VSS) was used to evaluate treatment response. For each subject, scar scores could range from 0 (normal) to 14 (purple, hyperpigmented, adherent, >6 mm; Table 1). VSS scores in both groups were assessed on day 7 and day 30 after suture removal by the Mohs surgeon and an independent dermatologist. A Patient Satisfaction Scale was used to assess overall satisfaction with treatment outcomes on a scale of 1 (Very Unsatisfied) to 5 (Very Satisfied) on day 30.
Pearson's chi-square test or Fisher's exact test was used to compare the categorical variables between the groups in the presence of expected values less than 5. To compare numerical variables between the groups, the Mann-Whitney test was used due to the absence of normal data distribution. The Wilcoxon test was used for related samples to compare the scores between the two evaluations in each group. To compare the numerical variables between groups and evaluations simultaneously, ANOVA for repeated measurements was used followed by the Tukey post hoc test for between-group comparisons, and the contrast profile test for comparison between the variables transformed into ranks due to the absence of normal distribution. For each test, P<0.05 was considered significant. Calculations were made with the SAS System for Windows, v. 9.2 (SAS Institute Inc., Cary, NC).