Subsequent treatment following a diagnosis of AD is reliant on treatment guidelines that reflect current knowledge. It is imperative, therefore, that AD treatment guidelines are updated regularly to reflect more accurately the risk–benefit profiles of systemic immunomodulators and to include newer treatment alternatives, particularly for moderate-to-severe AD cases. The advent of monoclonal antibodies aimed at targeting all aspects of the atopic disease spectrum may require us to revisit treatment algorithms, the implications of which would be far reaching, both for pharmaceutical drug development and in the establishment of guidelines for insurance-based drug formularies.
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