Multidisciplinary Real-World Experience With Bilastine, a Second Generation Antihistamine

February 2020 | Volume 19 | Issue 2 | Original Article | 145 | Copyright © February 2020


Published online February 11, 2020

Charles W. Lynde , Gordon Sussman , Pierre-Luc Dion , Lyn Guenther , Jacques Hébert , Jaggi Rao , Tim Vander Leek , Susan Waserman

aDepartment of Medicine, University of Toronto, Toronto, ON, Canada bDivision of Allergy/Clinical Immunology, University of Toronto, Toronto, ON, Canada cDivision of Dermatology, Université Laval, Québec, Québec, Canada; CISSS de Chaudière-Appalaches – Hôtel-Dieu de Lévis, Lévis, Québec, Canada dWestern University, London, ON. Royal College of Physicians and Surgeons of Canada, eDepartment of Medicine, Université Laval, Québec, Canada fDivision of Dermatology, University of Alberta, Edmonton, Alberta, Canada gDepartment of Pediatrics, Stollery Children’s Hospital, University of Alberta, Edmonton, Alberta, Canada hDivision of Clinical Immunology & Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada





Pruritus of unknown cause and pruritus associated with AD
Table 7 discusses two patients with pruritus: In case 9, the patient presents with pruritic symptoms due to an unknown cause, while case 10 involves a patient with AD-related pruritus. For these patients, education on their conditions, avoidance of pruritic triggers, and the implementation of a primary skincare plan using a moisturizer were essential to improving their condition. Second-generation AHs can sometimes help to treat pruritus related to AD, but not the AD itself. In case 10, bilastine is shown as an effective adjunct to AD treatment to control pruritus. However, adherence to therapy is important for success. Again, panel members emphasized that the sedation caused by using firstgeneration AH is not helpful in treating pruritus and can also cause serious side effects.1-6,12

Suggestions for bilastine use
Second generation AHs such as bilastine may work, even when other AHs do not. The effective clinical response in many of the presented patient cases was achieved not because treatment with first-generation AHs are ineffective but because the patient could not tolerate the first generation AH. It must be recognized that first-generation AHs have serious side effects significantly and negatively impacting QoL.

The panel members recommended that for pruritic conditions, bilastine is continued until all symptoms subside, usually, 1 to 2 months duration, up to 6 months, or longer if necessary. The panel suggested a minimum of 2–3 months with no condition activity or symptoms before discontinuing bilastine, after which the AH is taken as needed. In SAR an AH is to be taken for the duration of the pollen season, and those with PAR can take it indefinitely. In those patients with CSU the time they need to take AH varies considerably. Generally we treat until the disease is gone.

The panel members concluded that their task is not only to teach about the risks of first-generation sedating AHs but also to educate healthcare providers (including primary care physicians) and their patients on how and why they should use second-generation AHs.

The authors stated: “Bilastine is not available in the US, but it is in Canada, and we find it effective.” Although guidelines from the US recommend second-generation AHs, due to lack of availability, the choices are more limited.38

CONCLUSIONS

Second-generation AHs are thoroughly investigated in clinical pharmacology studies and randomized controlled trials. Every day clinical practice can pose challenges when selecting an effective and safe AH for the treatment of allergic conditions.The real-world cases presented here applied bilastine in conditions such as SAR, PAR, chronic urticaria, and less common but challenging conditions such as urticarial vasculitis and pruritus in